Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump.

Objective: To test the feasibility of an SC mini-infusion pump to deliver ceftazidime in dogs and produce plasma concentrations sufficient to reach a therapeutic target for 48 hours.

Setting: University research laboratory.

Animals: Six healthy Beagle dogs.

Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs.

Effective management of pain in animals is of critical importance but options are limited for treating acute pain in dogs on an outpatient basis. The objective of this study was to compare the plasma concentrations and pharmacokinetics of a concentrated solution of buprenorphine, 1.8 mg/ml (Simbadol™) administered intravenously, intranasally, and via the oral transmucosal (OTM) route in healthy male dogs.

Effects of housing environment on oral absorption of acetaminophen in healthy Beagles.

Objective: To evaluate the effects of housing environment on oral absorption of acetaminophen in dogs.

Animals: 6 healthy Beagles.

Procedures: Acetaminophen (325 mg, PO; mean dose, 31.

Pharmacokinetics of levofloxacin following oral administration of a generic levofloxacin tablet and intravenous administration to dogs.

Objective: To determine the pharmacokinetics of levofloxacin following oral administration of a generic levofloxacin tablet and IV administration to dogs and whether the achieved plasma levofloxacin concentration would be sufficient to treat susceptible bacterial infections.

Animals: 6 healthy adult Beagles.

Procedures: Levofloxacin was administered orally as a generic 250-mg tablet (mean dose, 23.