Publications by authors named "Melanie Labelle"
Study Design: Quasi-experimental pilot study.
Objectives: Evaluate the immediate effect of virtual reality (VR), gait-like muscle vibration (MV) and transcranial direct current stimulation (tDCS) combined or alone on neuropathic pain in individuals with spinal cord injury (SCI).
Setting: Inpatient rehabilitation centre.
Article Synopsis
- Real-world data is needed to understand treatment changes in psoriasis patients in Canada, focusing on switching, discontinuation, and dose adjustments.
- A study examining patient charts from 2005-2019 revealed that the medication adalimumab had the longest duration before treatment change, with around half of patients needing to change treatment mainly due to lack of efficacy.
- The analysis showed that dose optimization significantly increased drug survival, with similar long-term retention rates for adalimumab and ustekinumab after 132 months of treatment.
The oncolytic mutant vesicular stomatitis virus VSVΔ51 achieves robust efficacy in multiple extracranial tumor models. Yet for malignancies of the brain, direct intratumoral infusion of VSVΔ51 causes lethal virus-induced neuropathology. Here, we have developed a novel therapeutic regime that uses peripheral immunization with a single sub-lethal dose of VSVΔ51 to establish an acute anti-viral state that enables the safe intracranial (IC) infusion of an otherwise lethal dose of VSVΔ51 within just 6 hr.
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