Publications by authors named "Melanie L Langille"
Article Synopsis
- Adipose tissue can respond to thyroid-stimulating hormone (TSH), which increases lipolysis and the release of the cytokine IL-6 in fat cells.
- The study aimed to investigate how TSH activates two signaling pathways: protein kinase A (PKA) and IKK-β, and whether it also stimulates other cytokines.
- Results showed that TSH boosts certain enzyme activities and promotes the expression of another cytokine, MCP-1, highlighting TSH's role as a pro-inflammatory agent in fat cells.
Our objective was to identify the signaling pathway activated by TSH that induces IL-6 secretion from human abdominal sc differentiated adipocytes. Human abdominal sc preadipocytes in culture were differentiated into adipocytes. IL-6 release stimulated by TSH was inhibited by 35% (P < 0.
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