Publications by authors named "Melanie Heiss"
Article Synopsis
- The INFORM program targets pediatric patients with relapsed or refractory cancers through a molecular diagnostics approach, facilitating personalized treatment strategies with its registry and biomarker-driven trials.
- The INFORM2 NivEnt trial investigates the safety and efficacy of a combination therapy using nivolumab and entinostat in children and adolescents with high-risk solid or CNS tumors, adopting a two-phase design based on patient responses.
- A Bayesian adaptive design will enable the trial to halt ineffective treatment cohorts early, optimizing patient safety while focusing on identifying promising biomarkers for effective therapies.
