[Vaccination : when providence becomes mistrust].

Vaccination is a major stake of primary prevention but is increasingly weakened by its own success. The emergence of a category of patients known as « hesitant », largely influenced by mass media, jeopardizes future immunization coverage. To deal with these patients, whose doubts are fed on erroneous informations, lack of confidence in the health system and their own representations, communication about immunization is difficult, especially for the primary care physician who remains the principal interlocutor and the most reliable source of information for patients.

Value of non-identified ANCA (non-PR3, non-MPO) in the diagnosis of granulomatosis with polyangiitis (Wegener's granulomatosis).

Objective: Determine the frequency of granulomatosis with polyangiitis (GPA) associated with non-identified ANCA (non-MPO, non-PR3 ANCA) and secondarily compare their clinic with GPA associated with MPO-positive or PR3-positive ANCA.

Methods: In a monocentric retrospective observational study, clinical data of 398 patients with non-identified ANCA (titer of ANCA at least 1/80 by immunofluorescence on ethanol fixed PMN) was gathered over a period of 6 years. GPA patients from this population were compared with GPA patients with identified ANCA on the basis of clinical, biological, immunological and histological features.