Publications by authors named "Melanie Forrest"
Article Synopsis
- - A new platinum(IV) chemotherapeutic agent, HA-Pt(IV), was developed that activates immunogenic cell death (ICD) and shows antiproliferative effects on head and neck cancer cells both in mice and humans.
- - The HA-Pt(IV) treatment was tolerable and effective in both immune-competent and immune-deficient mice, leading to better survival rates in the immune-competent group, suggesting an immunological response.
- - Imaging of treated tumor tissues revealed increased macrophage infiltration and RNA sequencing highlighted the significance of carbohydrate and vitamin metabolism pathways, indicating a robust inflammatory response.
This case report documents the diagnosis, treatment, and outcome of a nonresectable oral squamous cell carcinoma in a dog with initial poor prognosis. An approximately 4-year-old female Staffordshire Bull Terrier presented with a large mass on the front of lower jaw which was diagnosed as oral papillary squamous cell carcinoma by histopathology. CT scans revealed invasion of the cancer to the frenulum of the tongue.
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