Publications by authors named "Melanie Brunelle"
Immunogenicity and protective efficacy of a single-dose live non-pathogenic Escherichia coli oral vaccine against F4-positive enterotoxigenic Escherichia coli challenge in pigs.
John Morris Fairbrother Éric Nadeau Louise Bélanger Cindy-Love Tremblay Danielle Tremblay Mélanie Brunelle
Vaccine
January 2017
Article Synopsis
- Enterotoxigenic Escherichia coli strains expressing F4 (F4-ETEC) are a significant cause of post-weaning diarrhea in pigs, and a study evaluated the effectiveness of an oral vaccine, Coliprotec® F4, to protect against this issue.
- The vaccine was administered to pigs one day after weaning, with results showing a notable decrease in diarrhea severity and F4-ETEC colonization and shedding, particularly at 7 and 21 days post-vaccination.
- The protective effects were linked to specific antibodies developed in pigs, indicating that the vaccine works well even in the presence of maternal antibodies and offers protection within just 7 days.
A new series of linear and permanently charged poly(amidoammonium) salts were synthesized in order to investigate the influence of their ionic and hydrophobic contents on both the cytotoxicity and the transfection mediated by polycation-DNA complexes. The poly(amidoammonium) salts were prepared by chemical modification of a parent poly(amidoamine) containing two tertiary amino groups per structural unit: one incorporated into the main chain and the other fixed at the end of a short bismethylene spacer. The permanent charges were introduced through a quaternization reaction involving iodomethane or 1-iodododecane as an alkylating agent.
View Article and Find Full Text PDF