Publications by authors named "Melanie A Rutkowski"
Article Synopsis
- Chemotherapy, particularly platinums, has been found to promote changes in lymphatic systems that could unintentionally enhance cancer malignancy instead of just inhibiting tumor growth.
- In experiments with mouse models and human patients, platinums induced systemic lymphangiogenesis, which is the formation of new lymphatic vessels, and this effect was shown to be dose-dependent and long-lasting.
- The study suggests that blocking these lymphatic changes with VEGFR3 inhibitors could improve treatment outcomes, advocating for adjustments in cancer therapies that involve platinum-based drugs.
