Increased lithium dose requirement in a hyperglycemic patient.

Objective: To report a case of apparent increased lithium clearance in a patient with persistent hyperglycemia.

Methods: Lithium doses, blood glucose concentrations, and lithium plasma concentrations were evaluated in a patient during a 53-day inpatient admission for exacerbation of bipolar disorder. The lithium dose required to increase the lithium plasma concentration by 0.