Publications by authors named "Melanie A Abboud"
J Cardiovasc Pharmacol
July 2008
Article Synopsis
- GW813893 is a new small molecule that selectively inhibits Factor Xa (FXa), showing promise as an oral antithrombotic therapy based on preclinical studies.
- The compound demonstrated strong inhibitory effects on FXa and prothrombinase with high selectivity, and successfully reduced thrombotic activity in various animal models without increasing bleeding risk.
- Overall, GW813893 exhibits the characteristics of a potent and safe oral anticoagulant, warranting further investigation for potential clinical use.
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