Publications by authors named "Melanie A Abboud"

Article Synopsis
  • GW813893 is a new small molecule that selectively inhibits Factor Xa (FXa), showing promise as an oral antithrombotic therapy based on preclinical studies.
  • The compound demonstrated strong inhibitory effects on FXa and prothrombinase with high selectivity, and successfully reduced thrombotic activity in various animal models without increasing bleeding risk.
  • Overall, GW813893 exhibits the characteristics of a potent and safe oral anticoagulant, warranting further investigation for potential clinical use.
View Article and Find Full Text PDF