Tumour protein 53 is linked with type 2 diabetes mellitus.

Background & Objectives: Tumour protein p53 (TP53) is a stress sensitive transcription factor responsible for the control of cell survival and death to prevent from tumour formation. In vitro and animal studies have indicated that TP53 also responds to metabolic changes and influences metabolic pathways. This study was undertaken to determine the serum level of TP53 and its correlations with clinical and biochemical parameters in type 2 diabetes mellitus (T2DM) patients in comparison to non-diabetic control individuals.

Association between single nucleotide polymorphisms of the G-protein γ5 subunit and the risk of essential hypertension in the population of Poland.

Introduction: Polymorphisms in genes coding G-protein subunits (α, β, and γ) may affect the response of stimulated α2A-adrenergic receptors, which are involved in the regulation of blood pressure. OBJECTIVES The aim of the present study was to determine the association between the rs11559300 (A/G), rs199705300 (C/A), rs61754630 (C/T), rs13093 (C/A), and rs41284589 (C/T) single nucleotide polymorphisms (SNPs) of the gene coding G-protein γ5 subunit (GNG5) and the risk of essential hypertension in the population of Poland.

Patients And Methods: A total number of 838 subjects were included in the study: 536 patients with diagnosed essential hypertension and 302 controls.

[The alternative method for albuminuria determination: second morning urine sample instead of 24-hour urine collection].

Unlabelled: Urinary albumin excretion is an established risk factor for renal and cardiovascular events. Measurement of albumin in the urine daily collection is the gold standard in assessing albuminuria. The 24-hour urine collection is cumbersome procedure that generates a lot of mistakes, therefore other methods have been proposed.