[Last-generation synthetic opioid analgesics as alternative to opiates in oncologic surgery].

The present-day problem is the development of effective methods of general anesthesia and postoperative anesthesia on the basis of nonopiate central analgesics possessing no hazardous side effects of opiates. A study was made of synthetic analgesics of the last generation as agents for intra- and postoperative anesthesia as compared with conventional opiates. It has been established that synthetic analgesics belonging to the class of opiate agonists-antagonists, namely moradol and norphine, compare favourably enough with fentanyl.

[General anesthesia in patients with spontaneous respiration].

Experimental studies performed on 97 alert rats and clinical studies in 930 cancer patients after extracavity surgery have demonstrated the advantage of the elaborated technique of total intravenous anesthesia of patients on spontaneous respiration with microdoses of diazepam, fentanyl, calypsol and droperidol over the current variants of inhalation and intravenous anesthesia with preserved spontaneous respiration. The technique elaborated is characterized by technical simplicity, efficacy, prompt postanesthetic rehabilitation of patients, safety for the personnel and economic benefits. The technique might be useful in mass injuries due to its minimum effect on the basic body functions and possibility of air breathing, with no special devices required.

[The new Soviet narcotic analgesic phenaridine as a component of general anesthesia during cancer surgery].

The results of studies on 65 cancer patients operated on under modified neuroleptanalgesia using fenaridine give evidence of a more potent and prolonged analgetic effect of a new Soviet narcotic analgesic fenaridine as compared to fentanyl. Fenaridine ensures stable neuroautonomous protection of the body during cancer surgery and is indicated in prolonged traumatic surgical interventions with cardiopulmonary bypass. Along with the above advantages fenaridine possesses all the complex of side effects typical of opiates associated with the depression of respiratory centres, psychoemotional sphere, activation of parasympathetic centres which may complicate the period following the patient's withdrawal from anesthesia and necessitate prolonged controlled lung ventilation in the early postoperative period.

[Tramal in the treatment of acute and chronic pain syndromes in cancer patients].

The study of 65 cancer patients has demonstrated the advantages and disadvantages of tramal as an agent used for the relief of acute and chronic pain syndrome. In 18 patients tramal was used in postoperative analgesia, in 17 patients it was used for the treatment of chronic pain syndrome. It has been shown that in the postoperative period tramal has no noticeable advantages over promedol.

[New data on tick-borne rickettsiosis in Novosibirsk Province].

New, so far unknown epidemically active natural foci of tick-borne rickettsiosis have been identified in Suzun District, Novosibirsk Province. The patients had a typical clinical pattern and epidemiological history of the disease. The cases were recorded in a number of communities in the northern forest-steppe zones.

[Synthetic analgesic moradol at various stages of surgical treatment of patients with cancer].

Moradol ("Galenika", Yugoslavia)/butorphanol tartrate ("Bristol--Mayers C.", USA)/, a synthetic analgesic representing a new generation of opiate receptors agonists-antagonists, devoid of any narcogenic potential has been used as the only analgesic at all stages of anesthesia during cancer surgery in 26 patients. For premedication moradol was used in a mean dose of 0.

[Epidemiological characteristics of Q fever foci in the Novosibirsk area].

Analysis of Q-fever morbidity and serological studies of representative extracts of population, agricultural and wild animals permitted to reveal the importance of inner-herd foci in epidemiology of this infection. It is shown that the level of registered morbidity mainly depends on the state of Q-fever laboratory diagnostics.

[Study of the relationships between the "locomotor regions" of the subthalamus and midbrain in rats].

Responses of single neurons in the midbrain tegmentum to stimuli applied to the subthalamic "locomotor region" were recorded extracellularly. In various units the latencies of responses were from 1 to 13 ms. Thresholds of the unit responses usually were not higher than the thresholds for eliciting locomotion.