Publications by authors named "Mel'nikova S"

Single crystals of silicon double salt (NH)SiF = (NH)SiF·NHF = (NH)[SiF]F were grown and studied by the methods of polarization optics, X-ray diffraction and calorimetry. A sequence of symmetry transformations with the temperature change was established: P4/mbm (Z = 2) (G) ↔ Pbam (Z = 4) (G) ↔ P2/c (Z = 4) (G) ↔ P1[combining macron] (Z = 4) (G) ↔ P2/c (Z = 8) (G). Crystal structures of different phases were determined.

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Single crystals of germanium double salt (NH4)3GeF7 = (NH4)2GeF6·NH4F = (NH4)3[GeF6]F were grown and studied by the methods of polarization optics and X-ray diffraction. The birefringence Δn = (no - ne), the rotation angle of the optical indicatrix ϕ(T) and unit cell parameters were measured in the temperature range 100-400 K. Three structural phase transitions were found at the temperatures: T1↓ = 279.

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The proposed method is intended for single-stage detection of A and B antigens in ultrafine hair fragments by means of absorption-elution and mixed agglutination techniques with the use of a mixture of anti-A and anti-B sera.

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On the basis of studying the intraoperative biopsy specimens in 44 patients with hepatic cirrhosis and portal hypertension syndrome, who had a distal splenorenal anastomosis been created, the authors have distinguished three types of morphological changes--A, B, C. A significant dependence between the type of cirrhosis and pronouncement of hepatic failure after the operation and life-time of a patient after the operation as well has been established. Type C has the greatest risk, type B requires differential approach, type A is prognostically favourable concerning both the outcome of the operation and life-time of a patient.

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Experiment on male rats has shown that acute stress suppressed amylase and superoxide dismutase activity in the submandibular salivary glands. The influence of short repeated stresses weakened the inhibiting effect of the acute stress on the activity of enzymes. A conclusion is drawn about the high sensibility of salivary glands to stress influences.

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During the autumn-winter epidemic of influenza-like diseases in December, 1983--first quarter, 1984, in Moscow commissioned coded observations on the effectiveness of prophylactic vaccination against influenza of 3-7-year-old children with a preparation "Grippovak SE-AZh" were carried out in day-care centers. In the previous large-scale trials, 1981-1984, the "Grippovak" had been evaluated positively as a completely harmless, serologically and immunologically active preparation reducing 3-3.5-fold the number of laboratory-verified cases of viral type A and B influenza in the vaccinees.

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In the process of the immunological approbation of several experimental batches of the triyalent subunit influenza vaccine Grippovac, the pronounced immunogenicity of the antigens of all strains contained in the vaccine was established; most of the vaccinees were found to retain sufficiently high antibody titers for a year, and the essential total increase of antibody titers was found to occur after a single booster immunization. The serological checking of the diagnosed cases of influenza among immunized and nonimmunized children, carried out in two boarding schools during the influenza epidemic in the winter of 1984-1985 provided the proofs of the high effectiveness of Grippovac in preventing viral influenza, types A and B: the decrease of influenza morbidity among the immunized children reached 79,5-67,2-66,5% and the total morbidity rate in influenza in these two boarding scholls dropped, on the average, 3,0-3,5 times.

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Experiments were carried out to clarify the effect of swelling coefficients of various samples of the polycondensation anion exchange resin FAF in the C1 form on its sorption properties. The anion exchange resin was used to eliminate contaminating proteins and low molecular weight agents from the allantois fluid and liver cultured cells of pigs. Thermal treatment of the anion exchange resin increased the coefficient of its swelling, leaving the structure unchanged.

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