Publications by authors named "Mejia R"

Introduction: While roll-your-own tobacco consumption is highest in Europe, increased sales are reported in Latin America. We are unaware of any research that explores the display and advertising of roll-your-own tobacco in this region.

Methods: An observational study was conducted at tobacco-selling points-of-sale (N=2,081) near schools in cities in Argentina, Guatemala, Mexico, and Peru between April and July 2023.

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Background: Laparoscopic gastrectomy offers advantages in the postoperative period compared to the open approach. Most studies have been performed on distal gastrectomies; however, laparoscopic total gastrectomy (LTG) is not universally accepted. AIM: The aim of this study was to assess the results of LTG, on postoperative morbidity outcomes and long-term survival.

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  • The study focused on detecting parasite DNA in soil from 34 houses in rural Yucatan, Mexico, using a specialized technique to highlight environmental reservoirs for human parasites.
  • Results showed that 65% of the houses had at least one type of parasite, with Acanthamoeba spp. being the most common, while some houses even had multiple parasites detected in a single sample.
  • This research emphasizes the significance of soil as a habitat for various parasites, which can pose health risks to rural communities, marking an important finding in the field of environmental health.
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  • Trichuris trichiura is a major soil-transmitted helminth infection affecting about 460 million individuals globally, with the Kato-Katz (K-K) method recommended for diagnosis by the WHO, despite its limitations.
  • A study within a clinical trial compared the effectiveness of K-K against real-time PCR in measuring treatment outcomes for T. trichiura, finding that PCR provided a better estimation of cure rates, particularly when using a combination of anthelmintics.
  • The results suggest that real-time PCR is a more reliable diagnostic tool in clinical trials for helminth infections and emphasize the need for consistent diagnostic standards across studies.
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  • The cortical thick ascending limb (CTAL) of the kidney was first characterized by Maurice Burg in 1973, revealing its role in actively reabsorbing NaCl while having low water permeability, allowing it to produce dilute urine during high water intake.
  • In the 1980s, Greger and Schlatter identified the specific membrane transport processes for NaCl, which were further characterized at the molecular level by various researchers in the 1990s using cDNA cloning and advancements in genome sequencing.
  • By the 2010s, mathematical models were developed to explore CTAL transport mechanisms, leading to investigations into Burg's 'static head' phenomenon, the adaptation of short CTALs in juxtamedullary nephrons,
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We discuss the potential usefulness of molecular testing of soil, dust, and water samples to detect medically important parasites, and where such testing could be used to supplement stool sampling in humans. A wide variety of parasites including protozoa and helminths, many of which are zoonotic, have an important infection reservoir in the environment. In some cases, this environmental period is essential for further parasite development.

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  • Soil-transmitted helminths (STHs) infect about 18% of the global population, presenting a health challenge and highlighting the limitations of traditional microscopy for diagnostics, especially in low-prevalence areas.
  • This study compared the effectiveness of different quantitative real-time PCR (qPCR) methods for detecting STH DNA in stool samples spiked with known quantities of STH eggs and larvae.
  • Results showed a strong correlation between qPCR outcomes and egg/larvae counts for most STHs tested, confirming qPCR as a reliable diagnostic tool, yet also indicating variability between methods and suggesting the need for further research to improve accuracy in parasite burden quantification.
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  • * A 5-year study involving the Helminth External Molecular Quality Assessment Scheme (HEMQAS) analyzed the proficiency of 36 laboratories in identifying helminths from stool samples, noting low false-positive rates but higher false-negative rates, particularly for certain species.
  • * The study found significant variability in diagnostic results among laboratories, attributed to differences in sample preparation and testing methods, highlighting the need for ongoing quality assessment in laboratory practices.
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Parasites are generally associated with lower income countries in tropical and subtropical areas. Still, they are also prevalent in low-income communities in the southern United States. Studies characterizing the epidemiology of parasites in the United States are limited, resulting in little comprehensive understanding of the problem.

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Vasopressin controls water permeability in the renal collecting duct by regulating the water channel protein, aquaporin-2 (AQP2). Phosphoproteomic studies have identified multiple proteins that undergo phosphorylation changes in response to vasopressin. The kinases responsible for the phosphorylation of most of these sites have not been identified.

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Background: Argentina's smoking rates remain high. We aim to estimate Argentina age-specific histories of smoking initiation, cessation, prevalence, and intensity by birth-cohort to inform policy interventions.

Methods: Modeling study.

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Background: The well-established inverse relationship between socioeconomic status (SES) and risk of developing coronary heart disease (CHD) cannot be explained solely by differences in traditional risk factors.

Objective: To model the role SES plays in the burden of premature CHD in Argentina.

Materials And Methods: We used the Cardiovascular Disease Policy Model-Argentina to project incident CHD events and mortality in low and high-SES Argentinean adults 35 to 64 years of age from 2015 to 2024.

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Aims: Protozoan and helminth parasitic infections pose significant public health challenges, especially in developing countries with rural populations marked by suboptimal hygiene practices and socio-economic constraints. The parasites are the etiological agents of these infections and have a notably elevated global prevalence. Therefore, this study focuses on estimating the frequency and transmission dynamics of several parasitic species, including Blastocystis, Giardia, Cryptosporidium spp.

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Patients with pulmonary fibrosis (PF) often experience exacerbations of their disease, characterised by a rapid, severe deterioration in lung function that is associated with high mortality. Whilst the pathobiology of such exacerbations is poorly understood, virus infection is a trigger. The present study investigated virus-induced injury responses of alveolar and bronchial epithelial cells (AECs and BECs, respectively) from patients with PF and age-matched controls (Ctrls).

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Background: Despite increasing availability of rapid molecular tests for the diagnosis of tuberculosis in high-burden settings, many people with tuberculosis are undiagnosed. Reliance on sputum as the primary specimen for tuberculosis diagnostics contributes to this diagnostic gap. We evaluated the diagnostic accuracy and additive yield of a novel stool quantitative PCR (qPCR) assay for the diagnosis of tuberculosis in three countries in Africa with high tuberculosis burdens.

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Chagas disease is a parasitic infection caused by . Diagnosis of chronic Chagas disease in dogs relies on limited serological test options. This study used a new Tc-24 recombinant antigen ELISA on an archival set of 70 dog serum samples from multi-dog kennel environments in Texas subjected to three existing Chagas serological tests.

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The amounts of parasite DNA in soil samples from different playgrounds and other public areas can help identify areas of possible microbe transmission and give indications of the possible occurrence of parasite infection in nearby communities. We collected 207 soil samples from parks in Paiute indigenous tribal areas in southwestern Utah and from the higher income city of St. George, Utah, and tested them for 11 parasites that can cause human disease.

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Zoonotic human infections with Ancylostoma ceylanicum have recently been reported in the Americas. We used archived human stool samples to study the geographic distribution of human infections with A. ceylanicum and anthropophilic hookworms in different geoclimatic regions (coastal, Andean, and Amazon) of Ecuador.

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Background: There are limited longitudinal data on the acquisition of Giardia lamblia infections in childhood using molecular assays to detect and type assemblages, and measure effects of infections on diarrhea risk and childhood growth.

Methods: We analysed stool samples from a surveillance sample within a birth cohort in a rural district in tropical Ecuador. The cohort was followed to 8 years of age for the presence of G.

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The amounts of parasite DNA in soil samples from different playgrounds and other public areas can help identify areas of possible microbe transmission as well as giving indications of possible occurrence of parasite infection in nearby communities. We collected 207 soil samples from parks located on Paiute indigenous tribal areas in southwest Utah and from higher income city of St. George, Utah, and tested them for the presence of 11 parasites that can cause human disease.

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Background: The measurement of substance use susceptibility was first conceived as part of the preparatory stage that precedes youth smoking initiation and is defined as the lack of a firm commitment not to smoke in the future. Despite being a consistent and validated predictor of smoking initiation, there has been little research on whether susceptibility can predict alcohol use. This study assessed the validity of an adapted alcohol susceptibility measure to predict alcohol consumption among early adolescent students in Argentina and Mexico who had not previously consumed alcohol.

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Most individuals at risk for or already experiencing mental disorders have no access to mental health care. Digital mental health interventions (DMHIs) can be effective in preventing and treating mental disorders. A taxonomy of digital interventions was previously proposed to organize the different types of digital tools being developed to expand mental health service delivery.

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