Precise Electrocatalysis on Fe-Porphyrin Conjugated Networks Achieves Energy-Efficient Extraction of Uranium.

Electrochemical extraction has the potential to enhance uranium (U) extraction capacity and rates, but thus far, high selectivity and energy efficiency have not been achieved through the design of electrode materials. Herein, a precise electrocatalysis strategy is developed using a Ferrum (Fe) porphyrin-phenanthroline conjugated network (Fe@PDACN) for energy-efficient uranium extraction. The phenanthroline provides specific binding sites for selective enrichment of U(VI) at active sites (K = 2.

Polyphosphonate-segmented macroporous organosilicon frameworks for efficient dynamic enrichment of uranium with in-situ regeneration.

Efficient separation and enrichment of uranium from radioactive effluents is of strategic significance for sustainable development of nuclear energy and environmental protection. Macropore structure of adsorbent is conducive to accessibility of the pore and transport of the adsorbate during dynamic adsorption. However, the low specific surface area results in fewer ligand sites and subsequently reduces the adsorption capacity.

Thermal-Responsive Conjugated Micropore Polymers for Smart Capture of Volatile Iodine.

The capture of radioiodine is crucial for nuclear security and environmental protection due to its volatility and superior environmental fluidity. Herein, we propose a strategy of "temperature-dependent gate" based on a swellable conjugated microporous polymer (SCMP) to significantly improve the capture of volatile iodine. The SCMP is constructed the Buchwald-Hartwig coupling reaction of building monomers containing amines.

Array electrochemiluminescence device with ultra-high sensitivity and selectivity for rapid visualized monitoring of trace radon in environment.

The World Health Organization has reported radioactive Rn gas as the second leading cause of lung cancer and gives an extreme limit to indoor Radon (Rn) concentration as 100 Bq/m. To realize rapid and accurate Rn monitoring, we report an efficient visualized electrochemiluminescence (ECL) device for Rn detection with the lowest limit of detection (0.9 Bq/m/3.

Visualized electrochemiluminescence iodine sensor based on polymer dots with Co-reactive group for real-time monitoring system.

Trace iodine (I) radioisotopes are commonly regarded as an indicator in nuclear security early warnings. Herein, we develop a visualized I real-time monitoring system using electrochemiluminescence (ECL) imaging technology for the first time. In detail, the polymers based on poly [(9,9-dioctylfluorene-alkenyl-2,7-diyl)-alt-co-(1,4-benzo-{2,1',3}-thiadiazole)] are synthesized for iodine detection.

Inhibition of endoplasmic reticulum stress alleviates triple-negative breast cancer cell viability, migration, and invasion by Syntenin/SOX4/Wnt/β-catenin pathway via regulation of heat shock protein A4.

Endoplasmic reticulum stress (ER stress) is a double-edged sword in the occurrence and development of malignant cancer. The aim of this study was to explore the roles of ER stress in metastasis and epithelial-mesenchymal transitionin triple-negative breast cancer (TNBC) and potential mechanisms. In this study, 4-PBA was administrated to inhibit the ER stress.

Two-Dimensional Imprinting Strategy to Create Specific Nanotrap for Selective Uranium Adsorption with Ultrahigh Capacity.

Uranium extraction is highly challenging because of low uranium concentration, high salinity, and a large number of competing ions in different environments. The template strategy is developed to address the defect of poor selectivity, but the adsorption capacity is limited by cavity blocking during the preparation of materials. Herein, a two-dimensional (2D) imprinting strategy is adopted to design 2D imprinted networks with specific nanotraps for effective uranium capture.

De Novo Design of a Pt Nanocatalyst on a Conjugated Microporous Polymer-Coated Honeycomb Carrier for Oxidation of Hydrogen Isotopes.

A booming demand for energy highlights the importance of an emergency cleanup system in the nuclear industry or hydrogen-energy sector to reduce the risk of hydrogen explosion and decrease tritium emission. The properties of the catalyst determine the efficiency of hydrogen isotope enrichment and removal in the emergency cleanup system. However, the aggregation behavior of Pt, deactivation effect of water vapor, and isotope effect induce a continuous decrease in the catalytic activity of the Pt catalyst.

Dual Ion-Imprinted Mesoporous Silica for Selective Adsorption of U(VI) and Cs(I) through Multiple Interactions.

Separation of uranium and cesium from low-level radioactive effluents (LLRE) is of great significance for sustainable development of the nuclear industry and for the environment. However, high salinity and massive coexisting ions of LLRE are giant challenges for the separation. To address the challenges, we report a strategy for efficient and simultaneous separation of uranium and cesium from a high-salt environment by dual ion-imprinted mesoporous silica based on multiple interactions.

Smart Oral Administration of Polydopamine-Coated Nanodrugs for Efficient Attenuation of Radiation-Induced Gastrointestinal Syndrome.

High-dose ionizing radiation can lead to death from the unrecoverable damage of the gastrointestinal tract, especially the small intestine. Until now, the lack of predilection for the small intestine and rapid clearance by digestive fluids limit the effects of conventional radioprotective formulations. Herein, an innovative radioprotective strategy is developed for attenuating gastrointestinal syndrome by smart oral administration nanodrugs.

Positively charged conjugated microporous polymers with antibiofouling activity for ultrafast and highly selective uranium extraction from seawater.

Uranium high-efficiency separation from seawater still has some obstacles such as slow sorption rate, poor selectivity and biofouling. Herein, we report a strategy for ultrafast and highly selective uranium extraction from seawater by positively charged conjugated microporous polymers (CMPs). The polymers are synthesized by Sonogashira-Hagihara cross-coupling reaction of 1,3-dibromo-5,5-dimethylhydantoin and 1,3,5-triethynylbenzene, and then modified with oxime and carboxyl via click reaction.

Petroleum pitch-based porous aromatic frameworks with phosphonate ligand for efficient separation of uranium from radioactive effluents.

Porous aromatic frameworks with structural/pore controllability and rigid skeletons present a series of emerging materials for solid phase extraction. However, the complicated monomers or noble metal catalyst, and cumbersome synthetic strategies result in high-cost engineering application of porous aromatic frameworks. Herein, a simple synthetic strategy of porous aromatic frameworks with phosphonate is reported for efficient separation of uranium from radioactive effluents, and petroleum pitch, a low-cost and widely available material, was used as the building block.

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery.

Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media.

Ultrasmall Hyperbranched Semiconducting Polymer Nanoparticles with Different Radioisotopes Labeling for Cancer Theranostics.

Exploiting ultrasmall nanoparticles as multifunctional nanocarriers labeled with different radionuclides for tumor theranostics has attracted great attention in past few years. Herein, we develop multifunctional nanocarriers based on ultrasmall hyperbranched semiconducting polymer (HSP) nanoparticles for different radionuclides including technetium-99m (Tc), iodine-131 (I), and iodine-125 (I) labeling. SPECT imaging of Tc labeled PEGylated HSP nanoparticles (HSP-PEG) exhibit a prominent accumulation in two-independent tumor models including subcutaneously xenograft and patient derived xenograft model.

A strategy for high radioprotective activity via the assembly of the PprI protein with a ROS-sensitive polymeric carrier.

With the rapid development and wide application of nuclear technology, radiation hazards present an enormous challenge for biological and medical safety. Currently, one of the major challenges in radiation protection is the discovery of more effective and less toxic radioprotectant agents. Herein, we present a strategy for high radioprotective activity via the assembly of the PprI protein with a reactive oxygen species (ROS)-sensitive polymeric carrier.

Phosphonate and carboxylic acid co-functionalized MoS sheets for efficient sorption of uranium and europium: Multiple groups for broad-spectrum adsorption.

It is significant to develop novel materials and techniques for efficient removal of radionuclides from radioactive wastes due to the radioactive and chemical toxicity. In this paper, we report a strategy for broad-spectrum adsorption of radionuclides by multiple groups-decorated adsorbents. Specifically, the adsorbents were prepared by grafting diethyl-(4-vinylbenzyl) phosphonate and maleic anhydride copolymers onto molybdenum disulfide sheets for the sorption of uranium(VI) and europium(III).

Cationic Polyarginine Conjugated Mesoporous Bioactive Glass Nanoparticles with Polyglycerol Coating for Efficient DNA Delivery.

Mesoporous bioactive glass (MBG) is a type of material with high biological activity and excellent biocompatibility. Because of its high specific surface area and adjustable surface morphology, MBG is usable for loading and delivering molecules. In our previous report, MBG particles were used as gene vectors and showed good transfection rate.

Polyglycerol grafting and RGD peptide conjugation on MnO nanoclusters for enhanced colloidal stability, selective cellular uptake and cytotoxicity.

An efficient surface engineering strategy for MnO nanoparticles was developed to attain enhanced colloidal stability, selective uptake by and toxicity to specific cancer cells. Specifically, MnO nanoclusters prepared by polyol method were grafted with polyglycerol (MnO-PG), and then conjugated with arginine-glycine-aspartate peptide (MnO-PG-RGD) through stepwise organic reactions. The physicochemical properties of the surface engineered MnO nanoclusters were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, dynamic light scattering, zeta potential, transmission electron microscopy and high-resolution transmission electron microscopy.

Polyglycerol mediated covalent construction of magnetic mesoporous silica nanohybrid with aqueous dispersibility for drug delivery.

Construction of nanohybrids with chemical and colloidal stability is of great importance for the exploration of their potential applications in biomedical field. In this work, a versatile strategy based on polyglycerol (PG) mediated covalent linkage is developed to fabricate a core-satellite nanohybrid, termed MMSN, consisting of a mesoporous silica nanoparticle (MSN) as a core and many superparamagnetic iron oxide nanoparticles (SPION) on the outer surface. In this synthetic strategy, the PG grafted SPION is derivatized to convert partial periphery hydroxyl groups to carboxyl moieties, followed by attachment to aminated MSN through amide bonds.

Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability.

Context: Duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1) is an acute and lethal disease of young ducklings. However, there is still no effective drug to treat DVH.

Objective: This study assessed the curative effect on DVH of a flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) as well as the hepatoprotective and antioxidative effects of BLIN.

Synthesis of chlorophyll-c derivatives by modifying natural chlorophyll-a.

Chlorophyll-a (Chl-a) was extracted from cyanobacterial cells and modified to methyl pyropheophorbide-a. The 3-vinyl-chlorin was transformed to zinc complex of the corresponding 3-acetyl-porphyrin. The zinc porphyrin was oxidized to give cis-7,8- and 17,18-dihydroxy-chlorins as well cis-7,8-cis-17,18-tetrahydroxybacteriochlorin.

The anti-DHAV activities of Astragalus polysaccharide and its sulfate compared with those of BSRPS and its sulfate.

This paper studied the anti-duck hepatitis A virus (DHAV) activities of Astragalus polysaccharide (APS) and its sulfate (sAPS) compared with those of Bush Sophora Root polysaccharide (BSRPS) and its sulfate (sBSRPS). The antiviral activities of APS and sAPS were measured by MTT and real-time PCR methods, in vitro. In vivo experiment, the mortality rate and the evaluation indexes of hepatic injury, peroxidative injury and immune level were measured.

Synthesis of chlorophyll-f analogs possessing the 2-formyl group by modifying chlorophyll-a.

A methyl group at the 2-position of methyl mesopyropheophorbide-a was transformed to the 2-formyl group to give methyl mesopyropheophorbide-f, one of the chlorophyll-f analogs. The 2-formylation moved the redmost electronic absorption band in a solution to a longer wavelength and the bathochromic shift was comparable to that by the 3-formylation. Zinc complex of the synthetic compound in solutions showed similar visible absorption spectra as those of naturally occurring chlorophyll-f.

Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis.

In order to study the antioxidant effect of Bush Sophora Root polysaccharide (BSRPS) and its sulfate on anti-duck virus hepatitis (DVH), sulfated Bush Sophora Root polysaccharide (sBSRPS) was prepared by chlorosulfonic acid-pyridine method. Ducklings were fed with BSRPS and sBSRPS after challenged DHAV. Death was monitored, evaluation indexes of peroxidative and hepatic injury at the initial (4th and 8th hour) and later (54th hour) stages were detected.

Photoreduction of zinc 8-vinylated chlorophyll derivative to bacteriochlorophyll-b/g analog possessing an 8-ethylidene group.

When a pyridine solution of zinc methyl 8-vinyl-mesopyropheophorbide-a was irradiated with visible light in the presence of ethanol, ascorbic acid and diazabicylo[2.2.2]octane under nitrogen at room temperature, zinc (7R/S,8E)-8-ethylidene-bacteriochlorin was obtained via 1,4-hydrogenation.