Defect Engineering in a Nanoporous Thulium-Organic Framework in Catalyzing Knoevenagel Condensation and Chemical CO Fixation.

Defect engineering is an extremely effective strategy for modifying metal-organic frameworks (MOFs), which can break through the application limitations of traditional MOFs and enhance their functionality. Herein, we report a highly robust nanoporous thulium(III)-organic framework, {[Tm(BDCP)(HO)](NO)·3DMF·2HO} (), with [Tm(COO)(HO)] chains and [Tm(COO)(HO)] dinuclears as metal nodes and 2,6-bis(2,4-dicarboxylphenyl)-4-(4-carboxylphenyl)pyridine (BDCP) linkers. In , each of the four chains of [Tm(COO)] and the two rows of [Tm(COO)(HO)] units is unified by the organic skeleton, resulting in a rectangular nanochannel with dimensions of 15.

Defect-engineered indium-organic framework displays the higher CO adsorption and more excellent catalytic performance on the cycloaddition of CO with epoxides under mild conditions.

In order to achieve the high adsorption and catalytic performance of CO, the direct self-assembly of robust defect-engineered MOFs is a scarcely reported and challenging proposition. Herein, a highly robust nanoporous indium(III)-organic framework of {[In(CPPDA)(HO)](NO)·2DMF·3HO} (NUC-107) consisting of two kinds of inorganic units of chain-shaped [In(COO)(HO)] and watery binuclear [In(COO)(HO)] was generated by regulating the growth environment. It is worth mentioning that [In(COO)(HO)] is very rare in terms of its richer associated water molecules, implying that defect-enriched metal ions in the activated host framework can serve as strong Lewis acid.

Neoadjuvant sintilimab plus chemotherapy for locally advanced resectable esophageal squamous cell carcinoma: a prospective, single-arm, phase II clinical trial (CY-NICE).

Background: Adding immune checkpoint inhibitors (ICIs) to the chemotherapy has shown significant clinical benefits in neoadjuvant treatment of locally advanced esophageal squamous cell carcinoma (ESCC). Sintilimab is one such ICI used for treatment. Herein, we designed a trial to evaluate the safety and efficacy of sintilimab combined with paclitaxel and platinum for locally advanced resectable ESCC.

Comparison of clinical efficacy of da Vinci robot-assisted lung cancer surgery with two-, three- and four-hole approaches.

Orifice reduction strategies for da Vinci robotic surgery have been a hot topic of research in recent years. We retrospectively analyzed the perioperative outcomes of robotic-assisted thoracoscopic surgery (RATS) with two, three, and four-hole approaches in radical lung cancer surgery. Our results revealed that the two-hole group has advantages in terms of operative time, postoperative 3-day drainage, postoperative drainage time, postoperative hospital stay and postoperative day 3 visual analogue scale (VAS) pain scores.

[Exploration of the Perturbation of PKIG in Lung Squamous Cell Carcinoma and the Role in Tumor Microenvironment Based on Bioinformatics Method].

Background: Lung cancer is the leading cause of cancer-related death worldwide, and patients have limited survival benefits from traditional treatments such as surgery, radiotherapy and chemotherapy. As a new treatment for lung cancer, immunotherapy has significantly prolonged the overall survival (OS) of patients. However, only some patients can benefit from it.

[Application Value of Artificial Intelligence-assisted Three-dimensional Reconstruction in Planning Thoracoscopic Segmentectomy].

Background: The three-dimensional (3D) can assist in planning lung segmentectomy. 3D reconstruction software based on artificial intelligence algorithm is gradually applied in clinic. The aim of this study was to evaluate the accuracy and safety of 3D reconstruction assisted planning of thoracoscopic segmentectomy.

[Clinical Study of Artificial Intelligence-assisted Diagnosis System in Predicting the Invasive Subtypes of Early-stage Lung Adenocarcinoma Appearing as Pulmonary Nodules].

Background: Lung cancer is the cancer with the highest mortality at home and abroad at present. The detection of lung nodules is a key step to reducing the mortality of lung cancer. Artificial intelligence-assisted diagnosis system presents as the state of the art in the area of nodule detection, differentiation between benign and malignant and diagnosis of invasive subtypes, however, a validation with clinical data is necessary for further application.

Slanted bilateral lateral rectus recession for convergence insufficiency-type intermittent exotropia: a retrospective study.

Background: The present study sought to investigate the efficiency and safety of slanted bilateral lateral rectus recession for the treatment of convergence insufficiency-type intermittent exotropia.

Methods: This retrospective study included 34 patients who underwent slanted bilateral lateral rectus recession for convergence insufficiency-type intermittent exotropia in Shandong Provincial Hospital affiliated to Shandong First Medical University between September 2013 and October 2015 with a minimum follow-up of 6 months. A successful surgical alignment was defined as + 5 (positive for esotropia) to - 10 (negative for exotropia) prism diopters (PD) of orthotropia in the primary position while viewing distant or near targets and a near-distance deviation difference ≤ 8PD.

Intraocular lens optic capture in pediatric cataract surgery.

Posterior capsule opacification (PCO) remains the most common complication of pediatric cataract surgery despite continuous efforts to reduce its incidence. For this reason, pediatric cataract surgeons have expended considerable effort into preventing and mitigating PCO. The intraocular lens (IOL) optic capture technique has been used for the prevention of PCO after pediatric cataract surgery for more than 20y, but there is still no professional consensus.

Far distance control scores for assessing intermittent exotropia.

Purpose: To assess the level of control in intermittent exotropia by applying the office-based 6-point control scale to far-distance testing.

Methods: Fifty-two children with intermittent exotropia were enrolled in this prospective, noninterventional case series. Control of exodeviation was assessed at indoor distance (ID) of 3 m and near distance of 33 cm using the office-based 6-point control scale, which was additionally applied to indoor far distance (IFD) fixation of 30 m and outdoor far distance (OFD) fixation of 50 m.

Visual outcomes of dense pediatric cataract surgery in eastern China.

Purpose: To evaluate the visual outcomes of dense pediatric cataract surgery in eastern China.

Methods: Medical records of children who underwent surgery for dense unilateral or bilateral pediatric cataract in Shandong Provincial Hospital between January 2007 and December 2012 were collected. Patients who cooperated with optical correction and aggressive patching of the sound eye and who had a minimum postoperative follow-up of more than 2 years were included.

Unilateral medial rectus resection for the treatment of recurrent exotropia in children.

Purpose: To investigate the outcomes of unilateral medial rectus resection (UMR-res) for the treatment of small to moderate angles of recurrent exotropia in children followed up for a minimum of 6 months.

Methods: This study is a retrospective, consecutive, interventional case series in which 48 children who underwent UMR-res (range 4.0-7.

Comparison of different surgery procedures for convergence insufficiency-type intermittent exotropia in children.

Aims: To compare prospectively the surgical outcomes of different surgery procedures for convergence insufficiency (CI)-type intermittent exotropia (IXT) in children.

Methods: Forty-five children with CI-type IXT were included in this prospective surgical study with 6 months follow-up. According to the different surgical procedures, all children were randomly divided into three groups: the unilateral medial rectus resection (UMR) group (15 cases), the bilateral medial rectus resections (BMR) group (14 cases) and the improved unilateral recession-resection (R&R) group (16 cases).

TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines.

Acanthamoeba keratitis (AK) is a painful, vision-threatening infection caused by pathogenic strains of the protozoan, Acanthamoeba. Toll-like receptors (TLRs), which are important components of innate immunity, have an important role in the detection of foreign pathogens and the signaling cascades in host cells. However, no report on the interaction between Acanthamoeba and TLR has been found.

Evaluation of three different methods to establish animal models of Acanthamoeba keratitis.

Purpose: To produce animal models of Acanthamoeba keratitis and to evaluate the advantages and adaptation range of each of the three methods employed.

Materials And Methods: Mice and Wistar rats in three groups of 15 rats and 15 mice each were used to establish the models. Right corneas in group A were scratched and challenged with Acanthamoeba.

Expression profiles and function of Toll-like receptors in human corneal epithelia.

Background: Toll-like receptors play an important role in the human immune system. This study was conducted to investigate the expression profiles and function of Toll-like receptor (TLR) 1 - 9 in human corneal epithelium.

Methods: The expression of TLR1 - 9 mRNA in 20 human donor corneal epithelia samples abraded during photorefractive keratotomy (PRK) and cultivated telomerase-immortalized human corneal epithelial cells (THCEs) was examined by semi-quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) analysis.

The role of NF-kappaB activation in lipopolysaccharide induced keratitis in rats.

Background: Nuclear factor-kappa B (NF-kappaB) is elevated in regulating transcription of many cytokines and inflammatory mediators. The purpose of this study was to investigate the activation and the significance NF-kappaB in lipopolysaccharide (LPS) induced keratitis.

Methods: LPS induced keratitis model was based on Wistar rats.