Controlled-release of cinnamaldehyde from MXene/ZIF8/gelatin composite coatings: An integrated strategy to combat implant-associated infection.

Infections and chronic inflammation surrounding titanium implants frequently impair angiogenesis and osseointegration, substantially heightening the risk of implant failure. In this study, titanium dioxide nanotube arrays (TN) were fabricated on titanium metal substrates to serve as reservoirs for cinnamaldehyde (CA). Subsequently, MXene and ZIF-8 were deposited onto the TN surface to seal the nanotube pores.

The impact of natural organic matter on the aggregation, dissolution and sedimentation of cadmium telluride quantum dots and their interacting mechanism.

This study investigated how natural organic matter (NOM) affected the aggregation, dissolution and sedimentation of cadmium telluride quantum dots (CdTe QDs) in artificial freshwater and seawater, with a focus on the impact of NOM species and the mechanism of CdTe QDs-NOM interactions. Results found that NOM dispersed CdTe QDs aggregates by providing electrosteric stabilization and promoted the dissolution by facilitating their contact in most cases. Among the tested NOM, fulvic acid (FA) was the most effective for releasing Cd in freshwater due to the strongest binding affinity complexing with CdTe QDs.

Hepatotoxic effect of DEP in zebrafish is via oxidative stress, genotoxicity, and modulation of molecular pathways.

Diethyl phthalate (DEP) is a commonly used phthalate ester (PAE) plasticizer known for its excellent plasticity and flexibility. Environmental exposure to DEP may have adverse effects on human health. Currently, few studies have focused on the specific effects and mechanisms on aquatic organisms.

Unveiling spatial heterogeneity in medulloblastoma: a multi-omics analysis of cellular state and geographical organization.

Background: Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear.

Methods: We analyze single-nucleus and spatial transcriptomes and chromatin accessibility from human MB spanning four subgroups, to identify malignant cell populations and describe the spatial evolutionary trajectories. The spatial CNVs patterns and niches were analyzed to investigate the cellular interactions.

Extracting organs of interest from medical images based on convolutional neural network with auxiliary and refined constraints.

Accurately extracting organs from medical images provides radiologist with more comprehensive evidences to clinical diagnose, which offers up a higher accuracy and efficiency. However, the key to achieving accurate segmentation lies in abundant clues for contour distinction, which has a high demand for the network architecture design and its practical training status. To this end, we design auxiliary and refined constraints to optimize the energy function by supplying additional guidance in training procedure, thus promoting model's ability to capture information.

Slow-release boron fertilizer improves yield and nutritional profile of L. grown in Northeast China by increasing boron supply capacity.

The northeastern part of China is a traditional sugar beet cultivation area where the soils are classified generally as the black and albic soil types with low boron (B) availability. Boron fertilizer can increase soil B content and significantly improve crop yield and quality. At present, the effects of slow-release B fertilizer on beet root yield and quality remain unclear.

Comparative transcriptome analysis and heterologous overexpression indicate that the ZjZOG gene may positively regulate the size of jujube fruit.

Background: Fruit size is a crucial economic trait that impacts the quality of jujube (Ziziphus jujuba), however, research in this area remains limited. This study utilized two jujube cultivars with similar genetic backgrounds but differing fruit sizes to investigate the regulatory mechanisms affecting fruit size through cytological observations, transcriptome sequencing, and heterologous overexpression.

Results: The findings reveal that variations in mesocarp cell numbers during early fruit development significantly influence final fruit size.

Varied chromosome distribution behaviours during meiosis in triploid Chinese chives contribute to the formation of viable pollen.

Triploids play an important role in the polyploidization process and are considered a bridge between diploids and polyploids. To inform plant polyploidization research and polyploid breeding, it is important to explore chromosome behaviour during triploid pollen development, pollen fertility problems in triploids and the potential value of utilizing triploids. In this study, acetocarmine, carbol fuchsin and fluorescence staining methods were used to observe microsporogenesis and microspore development in fertile triploid Chinese chives.

Parental Reconstruction from a Half-Sib Population of Stoneless Jujube Mill. Based on Individual Specific SNP Markers Using Multiplex PCR.

The selection of unique and individual-specific SNPs is important as compared with universal SNPs for individual identification. Therefore, the main significance of this research is the selection of specific SNPs in male parent and the identification of offspring with these specific SNPs in their genome by multiplex PCR, which is utilized for genotyping of 332 half-sib plants of .This cost-effective method makes as much as possible to utilize the same amount of each pair of various targeted loci primers.

Zinc and melatonin mediated antimicrobial, anti-inflammatory, and antioxidant coatings accelerate bone defect repair.

Inflammation and bacterial infection are important causes of implant failure, and the development of multifunctional titanium surfaces to address these issues is an effective means of treating infected bone defects. In this study, polyphenols (EGCG) and Zn were first loaded onto the titanium surface to construct an EGCG/Zn polyphenol metal network coating. Then melatonin (MT) was loaded into the EGCG/Zn network structure to prepare the EGCG/Zn/MT composite coating.

Diacylglycerol O-acyltransferase 2, a Novel Target of Flavivirus NS2B3 Protease, Promotes Zika Virus Replication by Regulating Lipid Droplet Formation.

Various lipid metabolism-related factors are essential for Zika virus (ZIKV) replication. In this study, we revealed a crucial role of diacylglycerol O-acyltransferase 2 (DGAT2) in ZIKV replication using a short hairpin RNA-based gene knockdown technique. The replication of ZIKV was significantly inhibited by DGAT2 depletion in multiple cell lines and restored by trans-complementation with DGAT2.

OsRopGEF10 Attenuates Cytokinin Signaling to Regulate Panicle Development and Grain Yield in Rice.

Cytokinins, which play crucial roles in shoot development, substantially affect grain yield. In rice, the OsRopGEF10-OsRAC3 module is associated with cytokinin signaling and crown root development. However, the effects of RopGEF-mediated cytokinin signaling on rice shoot development and grain yield remain unclear.

Research on the influencing factors of Chinese agricultural brand competitiveness based on DEMATEL-ISM.

Agricultural products are pivotal to the national economy, and a comprehensive analysis of brand competitiveness significantly contributes to the support of agricultural structural adjustment and modernization. Focusing on the Yangtze River Delta region of China, this study develops an evaluation index system encompassing four dimensions: core brand competitiveness, brand management, market competitiveness, and innovation in branding. Utilizing a DEMATEL-ISM model, this research elucidates the intrinsic relationships among factors that influence brand competitiveness, resulting in a four-tier hierarchical model.

Metal-Organic Framework Nanomaterials as a Medicine for Catalytic Tumor Therapy: Recent Advances.

Nanomaterials, with unique physical, chemical, and biocompatible properties, have attracted significant attention as an emerging active platform in cancer diagnosis and treatment. Amongst them, metal-organic framework (MOF) nanostructures are particularly promising as a nanomedicine due to their exceptional surface functionalities, adsorption properties, and organo-inorganic hybrid characteristics. Furthermore, when bioactive substances are integrated into the structure of MOFs, these materials can be used as anti-tumor agents with superior performance compared to traditional nanomaterials.

Magnetostrictive-piezocatalytic CoFeO@UiO-66 nanohybrid and its potential for deep-seated tumor treatment.

Magnetostrictive CoFeO (CFO) nanoparticles were encapsulated within a UiO-66 metal-organic-framework layer to form a CFO@UiO-66 nanohybrid. The deforming of CFO, in response to a high-frequency AC magnetic field, initiates the piezocatalytic property of UiO-66 to generate ˙OH radicals, which can kill cancer cells buried in thick tissues, showcasing bright potential for deep-seated tumor treatment.

Foliar zinc spraying improves assimilative capacity of sugar beet leaves by promoting magnesium and calcium uptake and enhancing photochemical performance.

Sugar beet, a zinc-loving crop, is increasingly limited by zinc deficiency worldwide. Foliar zinc application is an effective and convenient way to supplement zinc fertilizer. However, the regulatory mechanism of foliar zinc spraying on sugar beet leaf photosynthetic characteristics remains unclear.

ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging.

Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling correlative data have been generated to support the OS theory, a direct cause-and-effect relationship between the accumulation of oxidation-mediated damage and aging has not been firmly established. Superoxide dismutase 1 (SOD1) is a primary antioxidant in all cells.

Application of Se-Met to CdTe QDs significantly reduces toxicity by modulating redox balance and inhibiting apoptosis.

Cadmium tellurium quantum dots (CdTe QDs) as one of the most widely used QDs have been reported the toxicity and biosafety in recent years, little work has been done to reduce their toxicity however. Based on the mechanisms of toxicity of CdTe QDs on liver target organs such as oxidative stress and apoptosis previously reported by other researchers, we investigated the mechanism of action of trace element selenium (Se) to mitigate the hepatotoxicity of CdTe QDs. The experimental results showed that Se-Met at 40-140 μg L could enhance the function of intracellular antioxidant defense system and the molecular structure of related antioxidant enzymes by reduce the production of ROS by 45%, protecting the activity of antioxidants and up-regulating the expression of selenoproteins with antioxidant functions, Gpx1 increase 225% and Gpx4 upregulated 47%.

Establishing an evaluation index system of nursing quality for clinical drug trials: A Delphi study.

Aims: To construct a quality evaluation index system for clinical drug trials nursing management and obtain the weight of all indicators.

Design: A mixed-method research design with a quantitative component was used, primarily qualitative.

Methods: Through a literature review and semi-structured interview, an expert consultation questionnaire on the quality of nursing evaluation indicators for clinical drug trials was developed in April 2021.

The Key Metabolic Network and Genes Regulating the Fresh Fruit Texture of Jujube ( Mill.) Revealed via Metabolomic and Transcriptomic Analysis.

The texture of fresh jujube fruit is related to its popularity and commercial value. The metabolic networks and essential genes that regulate the texture of jujube () fruit are still unknown. In this study, two jujube cultivars with significantly different textures were selected by a texture analyzer.

Mitochondrial dysfunction in aging.

Aging is a complex process that features a functional decline in many organelles. Although mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of mitochondrial quality control (MQC) in aging is still poorly understood. A growing body of evidence points out that reactive oxygen species (ROS) stimulates mitochondrial dynamic changes and accelerates the accumulation of oxidized by-products through mitochondrial proteases and mitochondrial unfolded protein response (UPR).

Quantitative detection of naphthenic acids in wastewater based on superior fluorescence performance of nitrogen-rich carbon quantum dots.

With the development of the petrochemical industry, a large amount of naphthenic acids in petrochemical wastewater was accumulated in the environment, causing serious environmental pollution. Most of the commonly used methods for the determination of naphthenic acids have the characteristics of high energy consumption, complicated pretreatment, long detection cycle, and the need to send samples to analytical laboratories. Therefore, it is essential to develop an efficient and low-cost field analytical method for rapidly naphthenic acids quantify.

Risk factors and survival analysis of haemodialysis complicated with infective endocarditis.

The clinical features and risk factors for survival time were analysed in haemodialysis patients complicated with infective endocarditis. A total of 101 infective endocarditis (IE) patients treated at Hangzhou First People's Hospital, from January 1, 2012, to April 1, 2022, were included in the present study. Baseline demographic data and laboratory data were collected for statistical analysis of risk factors and survival time in the IE with haemodialysis group (HD-IE group, n=15) and the IE without haemodialysis group (NHD-IE group, n=86).

A deep learning model for detection of leukocytes under various interference factors.

The accurate detection of leukocytes is the basis for the diagnosis of blood system diseases. However, diagnosing leukocyte disorders by doctors is time-consuming and requires extensive experience. Automated detection methods with high accuracy can improve detection efficiency and provide recommendations to inexperienced doctors.

IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.

Objective: In the development of many tumors, IPO5, as a member of the nuclear transporter family, exerts a significant function. Also, IPO5 is used as a therapeutic target for tumors based on some reports. By studying IPO5 expression in esophageal cancer tissues, the mechanism associated with IPO5 improving esophageal cancer development was explored in this study.