Development of κ-carrageenan/tourmaline composite for active food packaging applications: Improved mechanical, gas barrier, and antimicrobial.

In order to solve the environmental pollution problems of traditional food packaging films, a kind of antibacterial packaging film based on κ-carrageenan and tourmaline powder was prepared. The addition of tourmaline powder as an inorganic filler improved the mechanical properties and gas barrier properties of κ-carrageenan films, and tourmaline had the function of spontaneously generating negative ions (NAIs) to give the film the antibacterial effect. With the increase in the amount of tourmaline powder, the water vapor permeability and oxygen permeability decrease, the water contact angle becomes larger, and the thermal degradation temperature increases.

Multidimensional analysis reveals gene expression, cell interactions, and signaling networks in glioma and Alzheimer's disease.

Background: This study employs a comprehensive approach using Genome-Wide Association Studies (GWAS), protein-protein interaction networks, gene co-expression networks, gene interaction networks, and centrality analysis to explore genetic and network interactions related to glioma and Alzheimer's disease.

Methods: Through detailed analysis of glioma single-cell data, we found that gene expression patterns are closely related to cell types and states. Principal Component Analysis (PCA) and dimensionality reduction techniques like UMAP and t-SNE reveal cell population heterogeneity and potential subgroups.

Preparation of light-responsive polyacrylamide/carboxymethyl chitosan composite aerogel and its adsorption performance for Li.

As an essential material for manufacturing lithium batteries, the demand of lithium is increasing, which means novel extracting method from various lithium-containing solutions is necessary. Spiropyran molecules undergo a photoisomerization reaction under light, transitioning from a closed-ring form (colorless) to an open-ring form (colored), generating multiple coordination sites to form coordination bonds with metal ions. In this paper, a polyacrylamide/carboxymethyl chitosan composite aerogel grafted with photoresponsive spiropyragroups (FeO/CNTs@PAM/CS-SP), used for extracting lithium from solutions, was prepared by dual cross-linking and vacuum freeze-drying.

Best Evidence Summary for the Prevention of Pressure Injuries in Orthopaedic Patients.

Aim: To systematically search, evaluate and synthesise the most robust evidence regarding pressure injury prevention in orthopaedic patients admitted to general wards.

Design: The present study provides an evidence-based summary of the most robust findings, adhering to the evidence guidelines established by the Center for Evidence-Based Nursing of Fudan University.

Method: According to the "6S" model, a systematic search was conducted for literature on pressure injury prevention among orthopaedic patients in general wards.

KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.

Glioblastoma (GBM) is highly invasive and lethal. The failure to cure GBM highlights the necessity of developing more effective targeted therapeutic strategies. KIF15 is a motor protein to be involved in cell mitosis promotion, cell structure assembly and cell signal transduction.

Muscle activation patterns and gait changes in unilateral knee osteoarthritis patients: a comparative study with healthy controls.

The objective of this study was to investigate the differences in muscle activation and kinematic parameters between patients with unilateral knee osteoarthritis (OA) and healthy individuals. Additionally, the study aimed to determine the correlation between muscle activation and kinematic parameters with knee OA symptoms. Participants with unilateral knee OA (n = 32) and healthy individuals (n = 32) completed the gait test.

Lumbrokinase Extracted from Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling.

As a kind of proteolytic enzyme extracted from , lumbrokinase has been used as an antithrombotic drug clinically. Nevertheless, its potential in anti-cancer, especially in anti-non-small cell lung cancer (NSCLC), as a single form of treatment or in combination with other therapies, is still poorly understood. In this study, we explored the anti-tumor role and the responsive molecular mechanisms of lumbrokinase in suppressing tumor angiogenesis and chemoresistance development in NSCLC and its clinical potential in combination with bevacizumab and chemotherapeutics.

[Research Progress of CAR-T Cell Immunotherapy in B-Cell Non-Hodgkin's Lymphoma--Review].

Chimeric antigen receptor T (CAR-T) cell therapy is a rapidly developing new immunotherapy in recent years. Compared with other therapies, CAR-T has significant advantages for high-risk and relapsed/refractory B cell non-Hodgkin's lymphoma (B-NHL) patients. Currently, a variety of anti-CD19 CAR-T cells have been approved by the FDA for the treatment of B-NHL, such as axicabtagene ciloleucel, tisagenlecucel, lisocababtagene maraleucel and brexucabtagene autoleucel.

No effect of autistic traits on social attention: evidence based on single-cue and conflicting-cues scenarios.

Individuals often use others' gaze and head directions to direct their attention. To investigate the influence of autistic traits on social attention, we conducted two experiments comparing groups with high and low autistic traits in single-cue (Experiment 1) and conflicting-cue (Experiment 2) scenarios. Our findings indicate that individuals responded more rapidly to the direction of a single social cue or the consensus of multiple cues.

Using phlebotomy to remove a difficult peripherally inserted central catheter insertion and removal in very low birth weight infants: case report of a rare complication.

Background: A peripherally inserted central catheter (PICC) is an important way to supply long-term intravenous infusion or parenteral nutrition for premature infants, especially very low birth weight (VLBW) infants. PICC removal difficulties occur mostly during use. It is rare to have difficulty removing a PICC due to reverse folding during catheterization.

[Research Progress of Targeted Therapy for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma --Review].

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a relatively inert B lymphocyte proliferative disease. In recent years with the launch of new drugs, chemotherapy has been gradually replaced by targeted therapy, which significantly prolongs the survival of patients and reduces the side effects of treatment. At present, BTK inhibitors, PI3K inhibitors, spleen tyrosine kinase (SYK) inhibitors and BCL-2 inhibitors are the most studied targeted therapeutic drugs for CLL/SLL.

RIscoper 2.0: A deep learning tool to extract RNA biomedical relation sentences from literature.

RNA plays an extensive role in a multi-dimensional regulatory system, and its biomedical relationships are scattered across numerous biological studies. However, text mining works dedicated to the extraction of RNA biomedical relations remain limited. In this study, we established a comprehensive and reliable corpus of RNA biomedical relations, recruiting over 30,000 sentences manually curated from more than 15,000 biomedical literature.

Simultaneous separation and determination of seven biphenyl cyclooctene lignans in Schisandra chinensis and its preparations by micellar electrokinetic chromatography with dual organic solvent system.

Introduction: Gomisin is a natural dibenzo cyclooctene lignan, which is mainly derived from the family Magnoliaceae. It has anti-inflammatory, antioxidant, anti-tumor, anti-aging, and hypoglycemic effects. Gomisins play important roles as medicines, nutraceuticals, food additives, and cosmetics.

Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of GTP cyclohydrolase 1 revealed in a novel mouse model.

Dopa and tetrahydrobiopterin (BH4) supplementation are recommended therapies for the dopa-responsive dystonia caused by GTP cyclohydrolase 1 (GCH1, also known as GTPCH) deficits. However, the efficacy and mechanisms of these therapies have not been intensively studied yet. In this study, we tested the efficacy of dopa and BH4 therapies by using a novel GTPCH deficiency mouse model, Gch1, which manifested infancy-onset motor deficits and growth retardation similar to the patients.

Quantification of Measurable Residual Disease Detection by Next-Generation Sequencing-Based Clonality Testing in B-Cell and Plasma Cell Neoplasms.

Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in post-treatment settings can be crucial for relapse risk stratification in patients with B-cell and plasma cell neoplasms. Prior studies have focused on validation of various technical aspects of the MRD assays, but more studies are warranted to establish the performance characteristics and enable standardization and broad utilization in routine clinical practice. Here, the authors describe an NGS-based IGH MRD quantification assay, incorporating a spike-in calibrator for monitoring B-cell and plasma cell neoplasms based on their unique IGH rearrangement status.

Efficacy of Autologous Hematopoietic Stem Cell Transplantation versus Chemotherapy or Allogeneic Hematopoietic Stem Cell Transplantation for Follicular Lymphoma: Systematic Review and Meta-Analysis.

Background: The effect of autologous hematopoietic stem cell transplantation (auto-HSCT) versus conventional chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT) on the survival of patients with advanced follicular lymphoma (FL) is uncertain.

Objectives: To elucidate this, FL and HSCT were used as keywords to search in PubMed, Embase, Web of Science, and Cochrane Library databases.

Method: After data extraction and quality evaluation, a total of 13 studies were included, seven of which compared auto-HSCT with conventional chemotherapy and the other six compared allo-HSCT with auto-HSCT to the survival of FL patients.

A sensitive liquid chromatography-tandem mass spectrometry method for determination biomarkers of monoamine neurotransmitter disorders in cerebrospinal fluid.

Background: Cerebrospinal fluid (CSF) monoamine neurotransmitters, their precursors and metabolites are essential biomarkers in the diagnosis and follow-up of monoamine neurotransmitter disorders (MNDs). However, their extra low concentrations and potential instability challenge the detection method. Here, we present a method that enables simultaneous quantification of these biomarkers.

Neutron collimator optimization for 14.1 MeV DT neutrons using Monte Carlo and Genetic algorithms.

The fast neutrons generated by Deuterium-Tritium (DT) fusion reaction have been widely applied in prompt gamma ray neutron activation analysis measurements. In this study, a multi-layer neutron collimator for DT neutron generator was developed. Genetic algorithm combined with Monte Carlo simulation was used to design a collimator made of iron, lead, graphite, and borated polyethene.

Clonal Characterization and Somatic Hypermutation Assessment by Next-Generation Sequencing in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Detailed Description of the Technical Performance, Clinical Utility, and Platform Comparison.

Somatic hypermutation status of the IGHV gene is essential for treating patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Unlike the conventional low-throughput method, assessment of somatic hypermutation by next-generation sequencing (NGS) has potential for uniformity and scalability. However, it lacks standardization or guidelines for routine clinical use.

Rice Water-Fried Atractylodis Rhizoma Relieves Spleen Deficiency Diarrhea by Regulating the Intestinal Microbiome.

Background: Spleen deficiency diarrhea (SDD) is a common Traditional Chinese Medicine (TCM) gastrointestinal condition, the causes of which include dysfunction of the intestinal barrier and microbiota. Rice water-fried Atractylodis Rhizoma (RAR) is a commonly used drug to treat this condition, but its mechanism remains unclear. This study explored the related mechanisms of ethanolic extract of rice water-fried Atractylodis Rhizoma (EAR) in the treatment of SDD by examining changes in the intestinal microbiota.

Preparation and Properties of Photoresponsive Pendimethalin@Silica-cinnamamide/γ-CD Microspheres for Pesticide Controlled Release.

Photocontrolled pesticide delivery systems have broad prospects for application in agriculture. Here, a novel photoresponsive herbicide delivery system was fabricated by functionalizing silica microsphere surfaces with cinnamamide and encapsulating the silica-cinnamamide with γ-cyclodextrin (γ-CD) to form a double-layered microsphere shell loaded with pendimethalin (pendimethalin@silica-cinnamamide/γ-CD). The microspheres showed remarkable loading capacity for pendimethalin (approximately 30.

Active projection nonlinear correction method for fringe projection profilometry.

In fringe projection profilometry (FPP), the luminance nonlinearity generated by the superimposed effect of the projector and camera can lead to distortion of the intensity of the sinusoidal phase-shift fringe, resulting in a reduction of measurement precision and resolution. Traditional phase error compensation and -correction methods need to focus on the projector's optimal performance. However, commercial projectors often have huge apertures and are, therefore, unable to project a perfectly focused sinusoidal fringe image.

RNADisease v4.0: an updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction.

Numerous studies have shown that RNA plays an important role in the occurrence and development of diseases, and RNA-disease associations are not limited to noncoding RNAs in mammals but also exist for protein-coding RNAs. Furthermore, RNA-associated diseases are found across species including plants and nonmammals. To better analyze diseases at the RNA level and facilitate researchers in exploring the pathogenic mechanism of diseases, we decided to update and change MNDR v3.