Publications by authors named "Meiyan Liu"

Douchi is a traditional Chinese fermented soybean product. In the Sichuan-Chongqing region, -type douchi was particularly famous for its distinctive flavor. Nevertheless, the association between microorganisms and douchi flavor is still poorly understood.

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Biohybrid systems that integrate microorganisms with nanomaterials have emerged as promising solutions for sustainable nitrogen fixation. However, key challenges, such as the dependence on light and the vulnerability of nitrogenase to oxidative damage, have limited their application. Here, we report a novel, light-independent biohybrid system integrating FeO nanoparticles with C2A, resulting in a significant enhancement of both nitrogen fixation activity and methane production.

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Fruit preservation materials play an instrumental role in preventing fruit deterioration and extending shelf life. However, existing fresh-keeping materials often prove inadequate in simultaneously achieving antibacterial properties, maintaining freshness, antioxidant effects, good biocompatibility, and prolonged fruit shelf life. Therefore, we present the first preparation of a natural polysaccharide spray hydrogel (Q/O/Zn hydrogel), loaded with chlorogenic acid‑zinc nanoparticles (CA@ZnNPs), utilizing quaternary ammonium insect chitosan (QECS) and oxidized pullulan (OPUL) for the preservation of perishable fruits.

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Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused by insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia and hypoxia. Long-term AP typically induces other cardiovascular events, including myocardial infarction and heart failure, posing a serious threat to patient safety. However, AP's complex pathological mechanisms and developmental processes introduce significant challenges in the rapid diagnosis and accurate treatment of its different subtypes, including stable angina pectoris (SAP), unstable angina pectoris (UAP), and variant angina pectoris (VAP).

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Purpose: The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery.

Methods: A total of 202 TNBC patients treated at Qingdao Central Hospital from January 2010 to December 2019 were included, comprising 71 HER2-low and 131 HER2-zero patients. Propensity score matching (PSM) was applied to minimize differences between the cohorts.

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Seed priming with nanomaterials is an emerging approach for improving plant stress tolerance. Here, we demonstrated a mechanism for enhancing salt tolerance in rice under salt stress via priming with nonstimulatory nanoparticles such as selenium nanoparticles (SeNPs), distinct from stimulatory nanomaterials. Due to the dynamic transformation ability of SeNPs, SeNP priming could enhance rice salt tolerance by mediating the glutathione cycle to eliminate excess reactive oxygen species (ROS).

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Article Synopsis
  • - Glycosylation and phosphorylation are important post-translational modifications that affect various biological processes and are linked to type 2 diabetes (T2D) due to abnormal protein translation.
  • - This study uses graphene oxide (GO) and titanium ions in chondroitin sulfate to create a material that effectively captures glycopeptides and phosphopeptides from blood serum.
  • - The method successfully isolated a significant number of glycopeptides and phosphopeptides from both normal and T2D serum, providing new insights into how these modifications can be monitored in relation to disease progression.
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Liver failure (LF) is prevalent in China and is characterized by complex pathogenesis, challenging clinical management, poor prognosis, and rising incidence and mortality rates. The immune status is an important factor affecting LF prognosis. Interleukins (Ils) are a type of cytokine that act and interact with multiple cells, including immune cells.

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  • This study investigates the causal link between 35 blood and urine biomarkers and oral leukoplakia (OLK), a condition that can indicate precancerous changes in the mouth.
  • Using a two-sample Mendelian randomization (MR) approach, they found five specific biomarkers that are significantly associated with OLK, highlighting both risk factors (like Apo B and LDL) and a protective factor (Non Albumin Protein).
  • The results suggest that while there is a causal relationship between these biomarkers and OLK, the exact mechanisms leading to the development of the condition are still unclear.
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Carrier-free self-assembly has gradually shifted the focus of research on natural products, which effectively improve the bioavailability and the drug-loading rate. However, in spite of the existing studies, the development of self-assembled natural phytochemicals that possess pharmacological effects still has scope for further exploration and enhancement. Herein, a nano-delivery system was fabricated through the direct self-assembly of Rhein and Matrine and was identified as a self-assembled Rhein-Matrine nanoparticles (RM NPs).

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  • The paper evaluates the effectiveness of three-dimensional ultrasonography (3DUS) and three-dimensional power Doppler (3DPD) in diagnosing ovarian cancer (OC), including their combined use.
  • After analyzing 2,566 studies, 18 were selected for the final review, revealing high sensitivity and specificity for both techniques, with 3DUS combined with 3DPD providing the best diagnostic performance.
  • The findings suggest that while both 3DUS and 3DPD are valuable diagnostic tools for OC, their combination significantly enhances diagnostic capability, making it a more efficient option.
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The increasing studies indicated that cardiovascular diseases, such as coronary artery disease (CAD), usually induce and exacerbate psychological problems, including anxiety and depression. These psychological issues are admitted as independent risk factors of heart disease as well. The interaction between CAD and anxiety and depression deteriorates the development and prognosis of CAD, which severely threatens the quality of life of patients.

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Boron-doped helicenes, known for their unique electronic and photophysical properties, are of great interest for numerous applications. This research introduces two new azabora[6]helicenes, H[6]BN1 and H[6]BN2, synthesized through an efficient method. These molecules have boron and nitrogen atoms in opposing positions, enhancing their distinctive attributes.

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Background And Objective: Non-small cell lung cancer (NSCLC) is a pernicious tumor with high incidence and mortality rates. The incidence rate of NSCLC increases with age and poses a serious danger to human health. The aim of this study was to determine the mechanism by which (-)-epicatechin (EC) alleviates NSCLC.

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This study aims to present a case of uterine adenomyosis accompanied by multiple hemorrhagic cerebral infarctions (CIs), summarize therapeutic experiences based on the literature review, and improve the clinical diagnosis and treatment of multiple hemorrhagic CIs. This paper describes a 46-year-old female with a four-year history of uterine adenomyosis complicated by multiple hemorrhagic CIs. During treatment, elevated levels of D-dimer, CA-125, and severe anemia were observed.

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Article Synopsis
  • * Key organic acids found in different tea types included quinic, citric, and malic acids in various teas, with ripe pu-erh tea showing high levels of oxalic and tartaric acids.
  • * A model was created to predict the sourness of tea based on the acids' composition, showing promising accuracy with a root-mean-square error of 0.58 and could help evaluate the quality of tea based on its chemical makeup.
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Background And Study Aims: Endoscopic submucosal excavation (ESE) and endoscopic full-thickness resection (EFTR) are common endoscopic minimally invasive methods for treatment of gastric submucosal tumors (SMTs). However, it is sometimes difficult to expose the tumor optimally. This study aimed to explore the safety and effectiveness of tumor traction using orthodontic rubber band (ORB) combined with clips to assist ESE and EFTR of gastric SMTs.

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  • Damage to the heart-brain connection causes cognitive decline, leading to perioperative delirium in patients undergoing coronary artery revascularization.
  • While symptomatic treatment is provided, many patients do not fully recover, resulting in high medium- and long-term mortality and adverse events.
  • The article emphasizes the need for further investigation into risk factors, incidence, and management strategies for delirium in these patients to enhance their prognosis.
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The study aimed to explore the relationship between family resilience, post-traumatic growth(PTG), and caregiver burden among family caregivers of stroke survivors. Researchers conducted a cross-sectional study to recruit 253 family caregivers of stroke survivors from a public hospital in Shandong Province, China. Caregivers completed sociodemographic information, the Shortened Chinese Version of the Family Resilience Assessment Scale, the Post-traumatic Growth Inventory, and the Zarit Caregiver Burden Interview.

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  • Cyanobacteria, key primary producers, are important for global carbon and nitrogen cycles, but the effects of nanoplastics on their nitrogen metabolism are not well understood.
  • Exposure to amino-modified polystyrene nanoplastics specifically affects nitrogen forms, leading to varied growth inhibition rates and altering their ability to process nitrogen.
  • The study reveals that different nitrogen types influence how nanoplastics disrupt cellular functions, leading to potential increases in harmful compounds like microcystin, highlighting the risks of nanoplastics in freshwater ecosystems.
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Methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria have become more common in recent years, which has made it extremely difficult to treat and heal many different kinds of wounds and caused enormous financial losses. Because of its unique "Trojan horse" function, Ga has been recognized as a new possible candidate for inhibiting and eradicating drug-resistant bacteria. Furthermore, natural polysaccharide materials with outstanding biological characteristics, such as insect chitosan (CS) and pullulan (PUL), have attracted significant interest.

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In compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we conducted this systemic review on the prevalence, mechanism, and therapy of sleep disorder in patients with cardiovascular disease (CVD). After searching PubMed and Embase, 78 articles were selected for this review. This review discusses the bidirectional relationship between CVD and sleep disorders.

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Objectives: This meta-analysis aimed to explore the association between inflammatory factors, heart rate variability (HRV) and the coexistence of coronary heart disease (CHD) and depression.

Design: Systematic review and meta-analysis. Complying with the Meta-analysis Of Observational Studies in Epidemiology statement.

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Therapy development for cancer and cardiovascular disease (CVD) to prolong lifespan makes the relationship between these two conditions more complex. Drug interactions in cardiology and oncology are associated with metabolism and drug transportation. Advances in biomarkers and imaging provide novel methods for detecting cardiotoxicity, including cardiac injury and inflammation.

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