HSG-MGAF Net: Heterogeneous subgraph-guided multiscale graph attention fusion network for interpretable prediction of whole-slide image.

Background And Objective: Pathological whole slide image (WSI) prediction and region of interest (ROI) localization are important issues in computer-aided diagnosis and postoperative analysis in clinical applications. Existing computer-aided methods for predicting WSI are mainly based on multiple instance learning (MIL) and its variants. However, most of the methods are based on instance independence and identical distribution assumption and performed at a single scale, which not fully exploit the hierarchical multiscale heterogeneous information contained in WSI.

Interpretable Inference and Classification of Tissue Types in Histological Colorectal Cancer Slides Based on Ensembles Adaptive Boosting Prototype Tree.

Digital pathology images are treated as the "gold standard" for the diagnosis of colorectal lesions, especially colon cancer. Real-time, objective and accurate inspection results will assist clinicians to choose symptomatic treatment in a timely manner, which is of great significance in clinical medicine. However, Manual methods suffers from long inspection cycle and serious reliance on subjective interpretation.

Effects of different concentrations of androgens on KAP24.1 gene expression in Hetian sheep and Karakul sheep.

The purpose of the experiment was to clone and eukaryotic expression of hair follicle keratin associated protein 24.1 (KAP24.1), study the effect of different concentrations of androgen on protein expression, and compare KAP24.

Interpretable classification of pathology whole-slide images using attention based context-aware graph convolutional neural network.

Background And Objective: Whole slide image (WSI) classification and lesion localization within giga-pixel slide are challenging tasks in computational pathology that requires context-aware representations of histological features to adequately infer nidus. The existing weakly supervised learning methods mainly treat different locations in the slide as independent regions and cannot learn potential nonlinear interactions between instances based on i.i.

A novel strategy regarding geometric product for liquids discrimination based on THz reflection spectroscopy.

A novel expression of geometric product that associated with the geometric relationship from geometric algebra constructed by the vectorized refractive index and absorption coefficient in THz region is proposed, which could provide a new insight into the THz properties of materials. From the novel expression, the candidate characteristic parameters are extracted for liquids discrimination and present the abundant second order correlation information of optical parameters with the consideration of dimension rising. Three groups of liquids, containing C-reactive protein calibrators and alpha fetoprotein calibrators, were selected as examples to validate the feasibility of the proposed strategy.

The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells.

In vitro induction of human primordial germ cell-like cells (hPGCLCs) provides an ideal platform to recapitulate hPGC development. However, the detailed molecular mechanisms regulating the induction of hPGCLCs remain largely uncharacterized. Here, we profiled the chromatin accessibility and transcriptome dynamics throughout the process of hPGCLC induction.

Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma.

The CXC chemokines belong to a family which includes 17 different CXC members. Accumulating evidence suggests that CXC chemokines regulate tumor cell proliferation, invasion, and metastasis in various types of cancers by influencing the tumor microenvironment. The different expression profiles and specific function of each CXC chemokine in head and neck squamous cell carcinoma (HNSCC) are not yet clarified.

Diagnosis of hepatocellular carcinoma based on a terahertz signal and VMD-CWSE.

A novel strategy on combining variational mode decomposition (VMD) and composite weighted-scale sample entropy (CWSE) modified from composite multiscale entropy (CMSE) is proposed to screen hepatocellular carcinoma (HCC) by measuring the terahertz (THz) pulse signals of ten normal and ten HCC serums. Eight measured HCC specimens are negative in serum biomarker alpha fetoprotein (AFP) determination. In CWSE, the time series with weighted-scales are generated from the weighted average processing in the coarse-grained time series corresponding to each scale of the CMSE algorithm.

[SiRNA inhibition of E6AP expression in cervical cancer cells].

Objective: To study the effect of RNA interference (RNAi) targeting E6AP on the proliferation and apoptosis of HeLa cells.

Methods: HeLa cells were cultured and divided into 3 groups: blank control group, cells transfected with nonsense siRNA (small interference RNA), and cells transfected with specific E6AP siRNA. The expressions of E6AP mRNA and protein were detected by RT-PCR and Western blot before and after the transfection respectively.

[Serum galectin-9 in cervical cancer].

Objective: To investigate the expression level of Galectin-9 (Gal-9) in the serum of cervical cancer patients and analyze the clinic significance of it.

Methods: Collected sera from 29 patients with cervical cancer, 45 patients with cervical inter-epithelial lesion (CIN) and 26 normal females. Determination of Gal-9 was performed by ELISA, and in the group of patients with cervical cancer, these results were compared with the serum vascular endothelial growth factor (VEGF) and C-reactive protein (CRP).

Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma.

Purpose: Galectin-9 (Gal-9) induces adhesion and aggregation of certain cell types and can be a prognostic factor in the patients with melanoma and breast cancer. We assessed the experiments to resolve whether Gal-9 expression in cervical neoplasm links to malignant potential of cervical squamous cell carcinoma (SCC) cells.

Methods: Gal-9 expression was examined with immunohistochemical techniques in 23 normal cervical squamous epithelia, 17 cervical intraepithelial neoplasia (CIN), and 38 cervical SCC compared to E-cadherin.