Publications by authors named "Meixuan Zhang"
Give the emergence of drug resistance in bacteria resulting from antibiotic misuse, there is an urgent need for research and application of novel antibacterial approaches. In recent years, nanoparticles (NPs) have garnered significant attention due to their potential to disrupt bacteria cellular structure through loading drugs and special mechanisms, thus rendering them inactive. In this study, the surface of hollow polydopamine (HPDA) NPs was utilized for the growth of Prussian blue (PB), resulting in the formation of HPDA-PB NPs.
View Article and Find Full Text PDFParkinson's disease (PD) is characterized not only by motor symptoms but also by non-motor dysfunctions, such as olfactory impairment; the cause is not fully understood. Our study suggests that neuronal loss and inflammation in brain regions along the olfactory pathway, such as the olfactory bulb (OB) and the piriform cortex (PC), may contribute to olfactory dysfunction in PD mice, which might be related to the downregulation of the trace amine-associated receptor 1 (TAAR1) in these areas. In the striatum, although only a decrease in mRNA level, but not in protein level, of TAAR1 was detected, bioinformatic analyses substantiated its correlation with PD.
View Article and Find Full Text PDFIncreasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson's disease (PD) treatment. Our previous research revealed a decreased abundance of (Akk) in PD mice; however, whether Akk is beneficial to PD is unknown. To answer this question, the mice received MPTP intraperitoneally to construct a subacute model of PD and were then supplemented with Akk orally for 21 consecutive days.
View Article and Find Full Text PDFArticle Synopsis
- Neuroinflammation plays a critical role in Parkinson's disease (PD), characterized by the activation of immune cells in the brain and the release of inflammatory substances.
- A study investigated the effects of inhibiting receptor-interacting protein kinase 1 (RIPK1) on neuroinflammation in PD using a mouse model, highlighting its elevated levels in PD brains.
- Results showed that inhibiting RIPK1 improved motor functions, reduced anxiety, and protected dopaminergic neurons, suggesting that targeting RIPK1 may provide potential therapeutic benefits for managing neuroinflammation in PD.
Article Synopsis
- Researchers can create functional organic molecules combined with metal-organic frameworks by changing the crystalline structure from ZIF-L to ZIF-8-L in two solvents.
- The new molecules/ZIF-8-L composites have a unique leaf-like appearance and show strong fluorescence properties.
- These composites also demonstrate size selectivity in fluorescent quenchers, benefiting from the microporous structure of ZIF-8-L which acts as a molecular sieve.