Chemotherapy plus therapeutic plasmapheresis with 4% human albumin solution in multiple myeloma patients with acute kidney injury: a prospective, open-label, proof-of-concept study.

As no unified treatment protocol or evidence yet exists for plasmapheresis without plasma, this study explored the outcomes of using 4% human albumin (ALB) solution as a replacement solution in patients undergoing plasma exchange for multiple myeloma (MM) patients with acute kidney injury (AKI). This study was prospectively registered (ChiCTR2000030640 and NCT05251896). Bortezomib-based chemotherapy plus therapeutic plasmapheresis (TPP) with 4% human ALB solution was assessed for three years in patients with MM aged >18 years, with AKI according to the Kidney Disease Improving Global Outcomes criteria, and without previous renal impairment from other causes.

R2R3-MYB transcription factor CsMYB60 controls mature fruit skin color by regulating flavonoid accumulation in cucumber.

Skin color is an important trait that determines the cosmetic appearance and quality of fruits. In cucumber, the skin color ranges from white to brown in mature fruits. However, the genetic basis for this important trait remains unclear.

Effect of alkali treatment on enzymatic hydrolysis of p-toluenesulfonic acid pretreated bamboo substrates.

The comprehensive separation and utilization of whole components of lignocellulosic materials has received extensive attention in present research. This study focused on the efficacy of alkali treatment for enzymatic saccharification of cellulose based on p-toluenesulfonic acid (p-TsOH) pretreated bamboo substrate. The results showed that the cellulose to glucose conversion yield was 94.

WeChat-based remote follow-up management reduces the burden of home care and anxiety on parents of children with refractory epilepsy: A randomized controlled study.

Objective: The present research was designed to study the effect of WeChat-based remote follow-up management on the burden of home care and anxiety on parents of children with refractory epilepsy.

Methods: 161 refractory epileptic children were included in this study. They were divided into control group and WeChat group according to their management protocols after discharge, namely, control group with traditional follow-up (n = 81) and WeChat group with remote follow-up based on WeChat (n = 81).

Pretreatment of moso bamboo with p-toluenesulfonic acid for the recovery and depolymerization of hemicellulose.

Bamboo and its mechanical processing residues have broad prospects for high value-added utilization. In this research, p-toluenesulfonic acid was used for the pretreatment of bamboo to investigate the effects of extraction and depolymerization of hemicellulose. The response and behavior of changes of cell-wall chemical components were investigated after different solvent concentration, time, and temperature pretreatment.

MnMoO-S nanosheets with rich oxygen vacancies for high-performance supercapacitors.

The structure of materials is closely related to their electrochemical properties. MnMoO materials have good stability as supercapacitors but their specific capacitance performance is not excellent. To improve electrochemical performance of MnMoO, this study conducts secondary hydrothermal treatment in thiourea solution on MnMoO electrode material grown on nickel foam synthesized by traditional hydrothermal method.

Would Household Medical Expenditure Affect Chinese Citizens to Have More Children?

This research investigates how household medical expenditure affects Chinese citizens having more children. We examined the causal relationship and found a negative influence of household medical expenditure on the willingness to have more children, confirming that increasing household expenditure on medical care may specifically decrease the high willingness. Chinese policymakers should adopt appropriate and effective strategies to mitigate the potential negative effects of household medical expenditure on the birthrate.

Enhancing the potential production of bioethanol with bamboo by γ-valerolactone/water pretreatment.

In this study, the effect of the γ-valerolactone (GVL)/HO pretreatment system on bamboo () for enzymatic hydrolysis and ethanol fermentation was investigated. The performance characterization of the pretreated bamboo substrates, including the chemical composition, the structural characteristics, and the ability to produce bioethanol, were evaluated. The recovered substrates were enzymatically hydrolyzed for 48 h and then fermented to bioethanol.

Enantioselective synthesis of chiral α-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines.

A SPINOL-derived chiral phosphoric acid catalyzed asymmetric formal [2 + 3]-annulation of in situ generated alkynyl imines and 1,4-dithiane-2,5-diol has been developed to afford enantiopure α-alkynylated thiazolidones with up to 72% yield and 98.5 : 1.5 er.

Regeneration of the Waste Selective Catalytic Reduction Denitrification Catalyst by Nitric Acid Washing.

In this study, the waste VO-WO/TiO denitrification catalysts from the coal-fired power plant were washed with water or nitric acid, followed by impregnating different contents of VO. The effects of the HNO concentration and the additional amount of vanadium on the low-temperature selective catalytic reduction denitrification activity were investigated under the condition of high concentration of SO and HO. The catalysts were characterized by inductively coupled plasma optical emission spectrometry, X-ray powder diffraction , N adsorption/desorption, H-temperature-programmed reduction, NH-temperature-programmed desorption , Fourier transform infrared spectroscopy , and Raman spectroscopy.

A rapid throughput assay for screening (R)-2-(4-hydroxyphenoxy)propionic acid producing microbes.

(R)-2-(4-hydroxyphenoxy)propionic acid ((R)-HPOPA) is an important intermediate for the synthesis of optically pure aryloxyphenoxypropionic acid herbicides. Regioselective hydroxylation of (R)-2-phenoxypropionic acid ((R)-POPA) by microbes is one of the most useful methods for the industrial production of (R)-HPOPA. In this study, we designed and optimized a rapid throughput assay for screening (R)-HPOPA producing bacterial/fungal strains which can regioselectively hydroxylate (R)-POPA.

Engineering extracellular matrix structure in 3D multiphase tissues.

In native tissues, microscale variations in the extracellular matrix (ECM) structure can drive different cellular behaviors. Although control over ECM structure could prove useful in tissue engineering and in studies of cellular behavior, isotropic 3D matrices poorly replicate variations in local microenvironments. In this paper, we demonstrate a method to engineer local variations in the density and size of collagen fibers throughout 3D tissues.