Publications by authors named "Meiwen Liu"
Article Synopsis
- The paper discusses the challenges in creating axially chiral compounds using gold(I) catalysis, particularly in asymmetric synthesis, which has seen limited progress.
- A new method is introduced that utilizes gold/HNTf cocatalysis for asymmetric diazo-alkyne annulation, successfully producing chiral biaryls and arylquinones with high yields and enantioselectivity.
- The study also extends this methodology to synthesize seven-membered-ring atropisomers and includes insights about the mechanism and role of HNTf through computational and experimental analysis.
The chemistry of quinone methides formed in situ has been flourishing in recent years. In sharp contrast, the development and utilization of biphenyl quinone methides are rare. In this study, we achieved a remote stereocontrolled 1,12-conjugate addition of biphenyl quinone methides formed in situ for the first time.
View Article and Find Full Text PDFCatalytic enantioselective construction of optically active tetraarylmethanes remains a challenging issue in the field of asymmetric synthesis because of the overwhelming steric hindrance and formidable stereocontrol that existed in construction of the all-aryl-substituted quaternary carbon stereocenter. Here, we reported an organocatalytic asymmetric synthesis of chiral tetraarylmethanes from racemic tertiary alcohols. With the aid of a chiral phosphoric acid catalyst, 6-methylenenaphthalen-2(6)-ones were generated in situ from 6-(hydroxydiarylmethyl)naphthalen-2-ols, followed by stereoselective 1,8-conjugate addition to afford the corresponding tetraarylmethanes in high to excellent yields with high enantioselectivities.
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