Publications by authors named "Meiting Zi"
Article Synopsis
- * Hypoxic conditions can lead to cellular damage and age-related health issues like heart disease, neurodegenerative disorders, and cancer by activating certain molecular mechanisms.
- * Potential treatments to counteract the negative impacts of hypoxia on aging include HIF modulators, antioxidants, and lifestyle changes, but challenges like individual differences in aging and safety of therapies highlight the need for personalized approaches.
Article Synopsis
- * Research showed that SnCs accumulate in DFUs, indicated by elevated markers and their secretory effects, which seem to hinder the healing process in chronic wounds compared to their potential benefits in acute wounds.
- * Targeting and clearing SnCs using a specific senolytic therapy significantly improved wound healing in a diabetic mouse model, suggesting that this approach could enhance treatment outcomes for patients suffering from DFUs.
Article Synopsis
- Liver diseases are a major public health issue, and drug development often faces challenges due to unwanted effects from treatments.
- This study introduces a new approach called Liver-Targeting Chimera (LIVTAC), which uses a special design to improve targeting and degradation of proteins specifically in the liver.
- The proof-of-concept agent, XZ1606, showed promising results by effectively suppressing tumors while reducing harmful side effects compared to traditional therapies, indicating LIVTAC's potential for treating various liver diseases.
Senescent cells (SnCs) are implicated in aging and various age-related pathologies. Targeting SnCs can treat age-related diseases and extend health span. However, precisely tracking and visualizing of SnCs is still challenging, especially in in vivo environments.
View Article and Find Full Text PDFImmunotherapy has revolutionized the established therapeutics against tumors. As the major immunotherapy approach, immune checkpoint inhibitors (ICIs) achieved remarkable success in the treatment of malignancies. However, the clinical gains are far from universal and durable, because of the primary and secondary resistance of tumors to the therapy, or side effects induced by ICIs.
View Article and Find Full Text PDFWhy Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development.
Front Cell Dev Biol
February 2022
Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in part via expressing the senescence-associated secretory phenotype. Elimination of SnCs has the potential to delay aging, treat age-related diseases and extend healthspan.
View Article and Find Full Text PDFTelomere is a unique DNA-protein complex which covers the ends of chromosomes to avoid end fusion and maintain the stability and integrity of chromosomes. Telomere length (TL) shortening has been linked to aging and various age-related diseases in humans. Here we recruited a total of 1031 Chinese individuals aged between 12 and 111 years, including 108 families with parents and their offspring.
View Article and Find Full Text PDFSenescent cells (SCs) accumulate with age and cause various age-related diseases. Clearance of SCs by transgenic or pharmaceutical strategies has been demonstrated to delay aging, treat age-related diseases and extend healthspan. SCs are resistant to various stressors because they are protected from apoptosis by SC anti-apoptotic pathways (SCAPs).
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