Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC.

Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism. Branched-chain keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme involved in BCAA degradation.

Achieving Enhanced Capacitive Deionization by Interfacial Coupling in PEDOT Reinforced Cobalt Hexacyanoferrate Nanoflake Arrays.

Capacitive deionization (CDI) as a novel energy and cost-efficient water treatment technology has attracted increasing attention. The recent development of various faradaic electrode materials has greatly enhanced the performance of CDI as compared with traditional carbon electrodes. Prussian blue (PB) has emerged as a promising CDI electrode material due to its open framework for the rapid intercalation/de-intercalation of sodium ions.

Bismuth Nanoparticle-Embedded Porous Carbon Frameworks as a High-Rate Chloride Storage Electrode for Water Desalination.

Capacitive deionization (CDI) is a promising cost-effective and low energy consumption technology for water desalination. However, most of the previous works focus on only one side of the CDI system, , Na ion capture, while the other side that stores chloride ions, which is equally important, receives very little attention. This is attributed to the limited Cl storage materials as well as their sluggish kinetics and poor stability.

Corin plays a protective role via upregulating MAPK and downregulating eNOS in diabetic nephropathy endothelial dysfunction.

Diabetic nephropathy (DN) is one of the leading causes of mortality in diabetic patients, but its pathogenesis is unclear. We aimed to study the role of the pro-ANP convertase Corin in the pathogenesis of DN. Corin and ANP expression in DN rat kidneys and high-glucose-treated HK-2 cells was analyzed by real-time PCR, western blotting, and immunohistochemical staining.

Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a leading contributor to the increased morbidity and mortality rates associated with diabetes. Persistent inflammation has previously been reported to be involved in the pathogenesis of DCM. However, the exact underlying molecular mechanisms remain to be fully elucidated.

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy.

Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood.