Infection of Human Macrophages by Is Influenced by Ecto-Nucleotidases.

Ecto-nucleotidase activity is involved in the infection process of and various other parasites that enables modulation of host immune responses to promote disease progression. One of the enzymes responsible for this activity is the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase). The enzyme hydrolyzes nucleotides tri- and/or di-phosphate into monophosphate products, which are subsequently hydrolyzed into adenosine.