Gut microbiome-immune interactions and their role in rheumatoid arthritis development.

Objective: The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on the development of rheumatoid arthritis.

Methods: This study was performed in Astana, Kazakhstan, and included 77 Kazakh female patients older than 18 years, who met the American College of Rheumatology 2010 classification criteria for rheumatoid arthritis (RA), and 113 healthy controls. The DNA was extracted from fecal samples obtained from all study participants for subsequent sequencing at the 16S rRNA gene V1-V3 locus, facilitating the analysis of the gut microbiome.

Oral Microbial Signature of Rheumatoid Arthritis in Female Patients.

This study aimed to identify the oral microbial signature of Kazakh female rheumatoid arthritis (RA) patients. A total of 75 female patients who met the American College of Rheumatology 2010 classification criteria for RA and 114 healthy volunteers were included in the study. Amplicons of the 16S rRNA gene were sequenced to analyze the microbial composition.

Association Study of Anticitrullinated Peptide Antibody Status with Clinical Manifestations and SNPs in Patients Affected with Rheumatoid Arthritis: A Pilot Study.

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology that leads to disability due to articular and extra-articular damage. RA prevalence is variable. The disease is most common among females with a 3 : 1 ratio.

DEPENDENCE OF BLOOD PRESSURE REACTIONS ON METEOROLOGICAL PARAMETERS IN VARIOUS AGE GROUPS.

Climate plays an essential role in the blood pressure (BP) regulation. BP seasonal fluctuations are often explained by meteorological factors, such as changes of outdoor temperature and etc. The 260 cases of BP monitoring of patients with uncomplicated hypertensive crisis were analyzed.

PLACENTAL GROWTH FACTOR AND MATERNAL CHARACTERISTICS IN THE FIRST TRIMESTER AMONG PREGNANT WOMEN OF KAZAKH NATIONALITY.

The impact of ethnicity and maternal anamnesis data at the PLGF level is determined. The aim of our study was to estimate changes at PIGF level in the first trimester of pregnancy, depending on the maternal anamnesis data among women of Kazakh ethnicity. 63 pregnant women at 12 weeks of gestation were included into the study.

PECULIARITIES OF THE COURSE OF GESTATION AND PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS.

Background: Gestational diabetes mellitus (GDM) is associated with high frequency of obstetric complications, such as gestosis, polyhydramnios, urogenital infection, premature birth. An increase in the number of cases of detection of GDM in pregnant women living in Kazakhstan is noted recently.

Objective: This research was carried out in order to see the influence of GDM on the course of the third trimester of pregnancy, outcomes and fetal status in women of Kazakh ethnic group.