Dinickel-Catalyzed Asymmetric Allylic Alkylation of Cyclic Ketones with Allylic Amine Derivatives.

A dinickel-catalyzed direct asymmetric allylic alkylation of benzocyclic ketones has been developed. This method enables the efficient transformation of various α-alkyl benzocyclohexanones and benzocyclopentanones with allylic sulfonamides, affording chiral ketones bearing α-quaternary carbon stereocenters in high yields and with excellent enantioselectivities.

[Roles of monocyte chemoattractant protein-1, RANTES and Fractalkine on promoting vulnerability of atherosclerotic plaques].

Objective: To elucidate the roles of monocyte chemotactic factors (MCP-1, RANTES and Fractalkine) on the vulnerability of atherosclerotic plaques in patients with stable (SAP) and unstable angina pectoris (UAP).

Methods: Patients with SAP (n = 50) and UAP (n = 50) underwent coronary angiography (CAG) and intravenous ultrasound (IVUS) were included in the study. Monocyte chemotaxis was assayed by the transwell chamber.