Publications by authors named "Meiqi Yee"
J Clin Microbiol
June 2018
Article Synopsis
- Next-generation sequencing (NGS) technologies can identify low-frequency HIV-1 drug resistance mutations (DRMs) better than traditional Sanger sequencing, leading to better patient outcomes.
- In a study comparing the Sentosa SQ HIV genotyping assay (NGS) with Sanger sequencing on 138 protease/reverse transcriptase and 39 integrase sequences, both methods showed a high concordance level of 99.9%.
- NGS detected additional DRMs not found by Sanger, with 18.2% of protease/RT sequences and 5.1% of integrase sequences showing higher resistance levels, suggesting improved sensitivity for detecting low-frequency DRMs.
