Comparative genomics of Fusarium species causing Fusarium ear rot of maize.

Fusarium ear rot (FER), caused by the fungal pathogen Fusarium verticillioides, stands as one of the most economically burdensome and pervasive diseases affecting maize worldwide. Its impact on food security is particularly pronounced due to the production of fumonisins, toxic secondary metabolites that pose serious health risks, especially for livestock. FER disease severity is complex and polygenic, with few resistance (R) genes being identified for use in breeding resistant varieties.

Winter diet of bats in working forests of the southeastern U.S. Coastal Plain.

Working forests comprise a large proportion of forested landscapes in the southeastern United States and are important to the conservation of bats, which rely on forests for roosting and foraging. While relationships between bat ecology and forest management are well studied during summer, winter bat ecology remains understudied. Hence, we aimed to identify the diet composition of overwintering bats, compare the composition of prey consumed by bat species, and determine the potential role of forest bats as pest controllers in working forest landscapes of the southeastern U.

Exploitation of Engineered Light-Switchable Myosin XI for Nanotechnological Applications.

For certain nanotechnological applications of the contractile proteins actin and myosin, ., in biosensing and network-based biocomputation, it would be desirable to temporarily switch on/off motile function in parts of nanostructured devices, ., for sorting or programming.

A LAMP Assay for Rapid Detection of the Pitch Canker Pathogen .

The pine pitch canker pathogen is endemic in the southeastern United States and Central America and represents an invasive threat globally. This ecologically adaptable fungus readily infects all parts of its pine hosts, leading to widespread mortality of nursery seedlings and decline in the health and productivity of forest stands. Because trees infected by can remain asymptomatic for long periods of time, accurate and rapid tools are needed for real-time diagnostics and surveillance at ports, in nurseries, and in plantations.

Nanolithographic Fabrication Technologies for Network-Based Biocomputation Devices.

Network-based biocomputation (NBC) relies on accurate guiding of biological agents through nanofabricated channels produced by lithographic patterning techniques. Here, we report on the large-scale, wafer-level fabrication of optimized microfluidic channel networks (NBC networks) using electron-beam lithography as the central method. To confirm the functionality of these NBC networks, we solve an instance of a classical non-deterministic-polynomial-time complete ("NP-complete") problem, the subset-sum problem.

Solving Exact Cover Instances with Molecular-Motor-Powered Network-Based Biocomputation.

Information processing by traditional, serial electronic processors consumes an ever-increasing part of the global electricity supply. An alternative, highly energy efficient, parallel computing paradigm is network-based biocomputation (NBC). In NBC a given combinatorial problem is encoded into a nanofabricated, modular network.

Explaining Semi-Supervised Text Alignment Through Visualization.

The analysis of variance in complex text traditions is an arduous task when carried out manually. Text alignment algorithms provide domain experts with a robust alternative to such repetitive tasks. Existing white-box approaches allow the digital humanities to establish syntax-based metrics taking into account the spelling, morphology and order of words.

Occipital Nerve Stimulation in Chronic Migraine: The Relationship Between Perceived Sensory Quality, Perceived Sensory Location, and Clinical Efficacy-A Prospective, Observational, Non-Interventional Study.

Introduction: Occipital nerve stimulation (ONS) is used to treat therapy-resistant chronic migraine. Clinical use has resulted in a wide intraindividual and interindividual variation of clinical efficacy. The aim of this study was to analyze a potential relationship between sociodemographic variables, headache parameters, perceived sensory quality, perceived sensory location, as well as clinical efficacy.

[Telephone enquiries on the topic of malignant hyperthermia: Evaluation of the content and subsequent diagnostic results at the MH Center Leipzig].

Background: Malignant hyperthermia (MH) is an autosomal dominant metabolic myopathy. The in vitro contracture test (IVCT) is still considered to be the gold standard for diagnosing a disposition for MH. However, advances in genetic testing for MH disposition have supplemented or even replaced the invasive procedure of the IVCT.

Imaging sensory effects of occipital nerve stimulation: a new computer-based method in neuromodulation.

Background: Within the last years, occipital nerve stimulation (ONS) has proven to be an important method in the treatment of severe therapy-resistant neurological pain disorders. The correspondence between lead placement as well as possible stimulation parameters and the resulting stimulation effects remains unclear.

Objective: The method aims to directly relate the neuromodulatory mechanisms with the clinical treatment results, to achieve insight in the mode of action of neuromodulation, to identify the most effective stimulation sets and to optimize individual treatment effects.

Blood/Gas partition coefficients for isoflurane, sevoflurane, and desflurane in a clinically relevant patient population.

Background: The blood/gas partition coefficient of a certain volatile anesthetic is of clinical importance because it determines its velocity of uptake into and elimination from the body of a patient and thus its pharmacokinetic behavior. To date, the blood/gas partition coefficients of isoflurane, sevoflurane, and desflurane have been measured in small numbers of subjects or in particular study groups, for example, healthy volunteers, patients experiencing a common kind of disease, or mothers immediately after giving birth. The objective of this study was to determine the blood/gas partition coefficients of these volatile anesthetics at 37°C in a larger clinically relevant and adult patient population.

Overview of the Publications From the Anthroposophic Medicine Outcomes Study (AMOS): A Whole System Evaluation Study.

Anthroposophic medicine is a physician-provided complementary therapy system that was founded by Rudolf Steiner and Ita Wegman. Anthroposophic therapy includes special medicinal products, artistic therapies, eurythmy movement exercises, and special physical therapies. The Anthroposophic Medicine Outcomes Study (AMOS) was a prospective observational multicenter study of 1631 outpatients starting anthroposophic therapy for anxiety disorders, asthma, attention deficit hyperactivity disorder, depression, low back pain, migraine, and other chronic indications under routine conditions in Germany.

Top-down influence on bottom-up process: the familiarity effect modulates texture segmentation.

This study deals with the familiarity effect (FE), which means that search performance is better when detecting an unfamiliar target in a familiar context compared to the detection performance of a familiar target in an unfamiliar context. In several experiments the spatial and temporal conditions were systematically varied to determine the ones which enable the appearance of the FE. Data were collected as a function of target eccentricity.

Spatial competition on the master-saliency map.

The saliency map model (Itti and Koch, 2000) is a hierarchically structured computational model, simulating visual saliency processing. Iso-feature processing on feature maps and conspicuity maps precedes cross-dimensional signal processing on the master map, where the most salient location of the visual field is selected. This texture segmentation study focuses on a possible spatial structure on the master map.

Electrophysiological correlates of target eccentricity in texture segmentation.

Event-related potentials and behavioural performance as a function of target eccentricity were measured while subjects performed a texture segmentation task. Fit-of-structures, i.e.

Texture segmentation: do the processing units on the saliency map increase with eccentricity?

The saliency map is a computational model and has been constructed for simulating human saliency processing, e.g. pop-out target detection (e.

Anthroposophic therapy for attention deficit hyperactivity: a two-year prospective study in outpatients.

Background: Anthroposophic treatment for attention deficit hyperactivity disorder (ADHD) includes special artistic and physical therapies and special medications.

Methods: We studied 61 consecutive children starting anthroposophic treatment for ADHD symptoms under routine outpatient conditions. Primary outcome was FBB-HKS (a parents' questionnaire for ADHD core symptoms, 0-3), and secondary outcomes were disease and symptom scores (physicians' and parents' assessment, 0-10) and quality of life (KINDL(®) total score, 0-100).

Pharmacokinetics and clinical toxicity of prilocaine and ropivacaine following combined drug administration in brachial plexus anesthesia.

Objective: Local anesthetics (LA) are often administered in combination for regional anesthesia in order to obtain the specific advantages (onset and duration of effect) of each drug. However, few data on the safety of such combinations are available and consequently plasma concentrations possibly associated with toxicity and interactions between the specific anesthetics are not sufficiently established. We measured pharmacokinetics and toxicity parameters of prilocaine and ropivacaine after combined use as single doses in brachial plexus blockade.

Mild clinical and histopathological features in patients who carry the frequent and causative malignant hyperthermia RyR1 mutation p.Thr2206Met.

Objective: Malignant hyperthermia (MH) is a classically unapparent pharmacogenetic disorder of the skeletal muscles triggered by inhalational anesthetics or depolarizing muscle relaxants. The disposition to MH is inherited in an autosomal-dominant manner and is primarily due to mutations in the gene for the ryanodine receptor type 1 (RyR1). The present study intended to analyze whether mild muscular symptoms (elevation of the resting CK, cramps in the calves, slight calf hypertrophy) may be associated with susceptibility to MH and/or with histopathological changes.

Spatial distance between target and irrelevant patch modulates detection in a texture segmentation task.

In three texture segmentation experiments a target patch had to be detected. We studied the impact of a task-irrelevant patch in the backward mask on detection performance, and especially the modulating effects of its spatial distance to the target. It was assumed that the signals of the two texture irregularities interact as a function of their spatial distance.

Anthroposophic therapy for children with chronic disease: a two-year prospective cohort study in routine outpatient settings.

Background: Many children with chronic disease use complementary therapies. Anthroposophic treatment for paediatric chronic disease is provided by physicians and differs from conventional treatment in the use of special therapies (art therapy, eurythmy movement exercises, rhythmical massage therapy) and special medications. We studied clinical outcomes in children with chronic diseases under anthroposophic treatment in routine outpatient settings.

A central performance drop with luminance stimuli requiring spatial integration.

This study reports four experiments that analyzed detection performance for luminance contrasts as a function of retinal eccentricity in order to find further support and explanations for the central performance drop (CPD) in the fovea. In the first experiment, 10 participants (16-37 years of age) had to detect a target patch in a stimulus consisting of bright and dark pixels. Luminance differences between target and context areas were achieved by placing a different number of bright (and dark) pixels in the target and the context area.

Attentional resources and pop-out detection in search displays.

Detecting pop-out targets is often considered as a fast, spontaneous and preattentive process. In most experimental studies, however, the observer's attention is explicitly focused on the detection task. We investigated pop-out detection under varying attention conditions: when pop-out displays were (a) not attended and not relevant, (b) attended and relevant and (c) could be attended but were not relevant.