Publications by authors named "Meindert E Manshande"
Article Synopsis
- Platelet transfusions can transmit infections, but the Mirasol Pathogen Reduction Technology uses riboflavin and UV light to make platelets safer by inactivating pathogens and white blood cells.
- This study reviewed the safety of Mirasol PRPTs given to critically ill infants in a NICU in Curaçao, covering data from February 2016 to April 2023.
- Out of 208 PRPTs given to 46 infants, no significant complications were observed, and although 46% of patients died during the study, these deaths were not associated with the transfusions, indicating that Mirasol PRPTs are safe for use in critically ill neonates.
Article Synopsis
- There are significant global disparities in access to genetic services, prompting the establishment of a joint pediatric-genetics clinic in the Dutch Caribbean in 2011, which aimed to address these challenges.
- A study of 331 patients who underwent genetic testing from 2011 to 2019 revealed that 33% received a confirmed molecular diagnosis, with the highest diagnostic yield noted in patients experiencing seizures and developmental issues.
- The findings indicated that genetic diagnoses led to significant changes in clinical management for 52% of patients, illustrating that even with limited resources, effective genetic services can improve patient care and outcomes.
Article Synopsis
- Research on patient and parent perspectives about genetic testing has primarily taken place in a few developed regions, leaving a gap in knowledge for places like the Dutch Caribbean.
- The study involved semi-structured interviews with 30 parents from Aruba, Bonaire, and Curaçao who received genetic diagnoses for their children's rare diseases, identifying key themes such as coping mechanisms and the unique challenges of living on small islands.
- Findings showed that despite challenges in healthcare access, most parents found value in receiving a genetic diagnosis, with insights specific to the Dutch Caribbean context, such as reliance on faith and dealing with social stigma.
The Caribbean part of the Kingdom of the Netherlands consists of six islands: Aruba, Bonaire, Curaçao, St. Maarten, St. Eustatius, and Saba.
View Article and Find Full Text PDFBackground: Perinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking.
Methods: We performed a prospective, non-controlled, observational study of infants infected before the age of 6 months with a severe chikungunya infection during the 2014-2015 epidemic in Curaçao, Dutch Antilles.
Autosomal-dominant hypertension and brachydactyly syndrome (HTNB; Bilginturan syndrome) is known to cause stroke before age 50 when untreated. We report a novel PDE3A gene mutation in a mother and daughter affected with dominant brachydactyly of the hands and feet, a short stature, and hypertension. The hypertension was medically responsive to anti-hypertensive treatment.
View Article and Find Full Text PDF