Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.

Objective: Diabetic nephropathy (DN) manifests a critical aspect in the form of renal tubular injury. The current research aimed to determine the function and mechanism of long non-coding ribonucleic acid (LncRNA) differentiation antagonising non-protein coding RNA (DANCR), with a focus on its impact on renal tubular injury.

Methods: Quantitative reverse transcription polymerase chain reaction was employed to analyze the RNA levels of DANCR in the serum of patients with DN or human proximal tubular epithelial cells (human kidney 2 [HK2]).

Ruthenium-Mediated [2 + 2 + 2] Cyclization: A Route to Forge Indane and Isoindoline Core and Its Application in DNA-Encoded Library Technology.

Indane and isoindoline are attractive bicyclic systems in biologically active compounds but are rarely reported in DNA-encoded libraries. In this paper, we reported an efficient and versatile approach for assembling indane and isoindoline scaffolds via a ruthenium-catalyzed [2 + 2 + 2] cyclotrimerization reaction. This method exhibits a broad substrate scope and has been successfully applied to construct a 53K-membered DNA-encoded library (DEL).

Macromolecular Probe Based on a Ni/Tb Coordination Polymer for Sensitive Recognition of Human Serum Albumin (HSA) and MnO.

Reported here are the design and fluorescence characters of a Ni/Tb polymer, [TbNi(HCAM)(HO)] () (HCAM = chelidamic acid). Under physiological conditions, the binding of biocompatible water soluble to human serum albumin (HSA) was studied by spectroscopy techniques, which revealed that could inherent the fluorescent light of HSA in a static quencher course and change the HSA second-level structure. The marked enhancement in and its fluorescence intensity provide conclusive evidence that can play the role of a "turn-on" sensor for recognition and detection of HSA in other biological interferents with a value of 7.

Adaptive iterative learning control of a class of nonlinear time-delay systems with unknown backlash-like hysteresis input and control direction.

This paper presents an adaptive iterative learning control scheme for a class of nonlinear systems with unknown time-varying delays and control direction preceded by unknown nonlinear backlash-like hysteresis. Boundary layer function is introduced to construct an auxiliary error variable, which relaxes the identical initial condition assumption of iterative learning control. For the controller design, integral Lyapunov function candidate is used, which avoids the possible singularity problem by introducing hyperbolic tangent funciton.

Determination of 17beta-oestradiol by fluorescence immunoassay with streptavidin-conjugated quantum dots as label.

A sensitive and selective method for the determination of 17beta-oestradiol by fluorescence immunoassay (FIA) was established on the basis of quantum dots (QDs) as label. The complex of biotin-labelled anti-rabbit IgG and strepavidin conjugated by quantum dots (QD-SA) was regarded as a probe in this system and the strepavidin-biotin system as signal amplification system. After optimising the conditions of the immunoreaction, such as the concentration of the reagent and the pH of the buffer solution, the linear range and the limit of detection of 17beta-oestradiol were 0.