Oxidative stress activates Ryr2-Ca and apoptosis to promote PM-induced heart injury of hyperlipidemia mice.

The increased cases of hyperlipemia in China and the crucial role of PM in inducing and promoting cardiovascular diseases have attracting more and more researchers' attention. However, the effects and mechanisms of PM on cardiovascular system of hyperlipidemia people are still unclear. In this study, hyperlipidemia mice model was established by high-fat diet.

Oxidative stress activates the TRPM2-Ca-NLRP3 axis to promote PM-induced lung injury of mice.

PM, a main particulate air pollutant, poses a serious hazard to human health. The exposure to PM increases mortality and morbidity of many respiratory diseases such as asthma, chronic obstructive pulmonary diseases and even lung cancer. The contribution of reactive oxygen species (ROS) in the PM-induced acute lung injury process was confirmed in our previous research, but the molecular mechanism based for it remains unclarified.

The harmful effects of acute PM exposure to the heart and a novel preventive and therapeutic function of CEOs.

Epidemiological researches have demonstrated the relationship between PM exposure and increased morbidity and mortality of cardiovascular injury. However, no effective therapeutic method was established. The purpose of this study is to investigate the effect of acute PM exposure on the mice heart tissue and explore the therapeutic effects of compound essential oils (CEOs) in this model.

A Weighted Spatial-Spectral Kernel RX Algorithm and Efficient Implementation on GPUs.

The kernel RX (KRX) detector proposed by Kwon and Nasrabadi exploits a kernel function to obtain a better detection performance. However, it still has two limits that can be improved. On the one hand, reasonable integration of spatial-spectral information can be used to further improve its detection accuracy.

Using aripiprazole to reduce antipsychotic-induced hyperprolactinemia: meta-analysis of currently available randomized controlled trials.

Background: Hyperprolactinemia (HPL) is a common side effect of antipsychotic medications. Recent reports suggest that aripiprazole can ameliorate antipsychotic-induced HPL, but results are inconsistent and the single available systematic review only considered five studies.

Aim: Conduct an updated meta-analysis of all randomized controlled trials (RCTs) about the efficacy and safety of aripiprazole as an adjunctive treatment for antipsychotic-induced hyperprolactinemia.