Increased risk of adverse gestational outcomes in pregnant women with primary Sjögren's syndrome.

Objectives: This study aimed to identify risk factors contributing to diverse pregnancy outcomes in primary Sjögren's syndrome (pSS) cases.

Methods: A retrospective analysis was conducted on pregnant individuals with pSS, who received outpatient or inpatient care across multiple hospitals in Anhui Province, China, from January 2015 to December 2022.

Results: This study included 164 pregnant women with pSS and 328 control subjects, with no statistically significant difference in average age between the two groups.

Pirfenidone Attenuates the EMT Process and the Secretion of VEGF in TGF-2-Induced ARPE-19 Cells via Inhibiting the Activation of the NF-B/Snail Signaling Pathway.

Aim: Pirfenidone (PFD), an antifibrotic drug, has various beneficial functions such as antioxidant, antifibrotic, and anti-inflammatory effects. This study aimed to explore the molecular mechanisms underlying how PFD modulates retinal pigment epithelial (RPE) cells involved in neovascularization and subretinal fibrosis.

Methods: ARPE-19 cell lines were treated with transforming growth factor-beta 2 (TGF-2) alone or in combination with PFD.

AGTR1 blocker attenuates activation of Tenon's capsule fibroblasts after glaucoma filtration surgery via the NF-κB signaling pathway.

Activation of Tenon's capsule fibroblasts limits the success rate of glaucoma filtration surgery (GFS), the most efficacious therapy for patients with glaucoma. Angiotensin type 1 receptor (AGTR1) is involved in tissues remodeling and fibrogenesis. However, whether AGTR1 is involved in the progress of fibrogenesis after GFS is not fully elucidated.