Outcomes of partial pulpotomy in permanent molars of children with irreversible pulpitis: A prospective cohort study.

Background: Vital pulp therapy is gaining traction in dental practice, especially for young patients.

Aim: To evaluate the outcomes of partial pulpotomy in permanent molars of children diagnosed with irreversible pulpitis (IP) using iRoot BP Plus.

Design: A total of 94 permanent molars in 88 patients, aged 6-15 years, with symptoms of IP, were treated with partial pulpotomy, using iRoot BP Plus as the pulp capping agent.

Smartphone Imaging Device for Multimodal Detection of Hydrogen Sulfide Using Cu-Doped MOF Sensors.

Multimodal sensing platforms may offer reliable, fast results, but it is still challenging to incorporate biosensors with high discriminating ability in complex biological samples. Herein, we established a highly sensitive dual colorimetric/electrochemical monitoring approach for the detection of hydrogen sulfide (HS) utilizing Cu-doped In-based metal-organic frameworks (Cu/In-MOFs) combined with a versatile color selector software-based smartphone imaging device. HS can result in the enhancement of the electrochemical signal because of the electroactive substance copper sulfide (CuS), the decrease of the colorimetric signal of the characteristic absorption response caused by the strong coordination effect on Cu/In-MOFs, and the obvious changes of red-green-blue (RGB) values of images acquired via an intelligent smartphone.

A rare case of TFEB/6p21/VEGFA-amplified renal cell carcinoma diagnosed by whole-exome sequencing: clinicopathological and genetic feature report and literature review.

Background: TFEB/6p21/VEGFA-amplified renal cell carcinoma (RCC) is rare and difficult to diagnose, with diverse histological patterns and immunohistochemical and poorly defined molecular genetic characteristics.

Case Presentation: We report a case of a 63-year-old male admitted in 2017 with complex histomorphology, three morphological features of clear cell, eosinophilic and papillary RCC and resembling areas of glomerular and tubular formation. The immunophenotype also showed a mixture of CD10 and P504s.

[Application of bioactive ceramics iRoot BP Plus in pulpotomy for complicated crown fracture of immature permanent anterior teeth in children].

Objective: To analyze the clinical and radiographic effectiveness of a calcium silicate-based bioactive ceramic iRoot BP Plus pulpotomy of immature permanent teeth with complicated crown fracture and to evaluate the factors influencing its long-term success rate.

Methods: The digital medical records of patients under 13 years old who had undergone iRoot BP Plus pulpotomy in the Department of Oral Emergency or the First Clinical Division, Peking University School and Hospital of Stomatology from March 2017 to September 2022 due to complicated crown fracture of anterior teeth, and had taken at least one post-operation apical radiograph were reviewed. The clinical and radiographic information at the initial examination and follow-up period were obtained, including crown color, mobility, percussion, cold test (partial pulpotomy teeth), dental restoration, fistula, swelling or inflammation of the gingival tissue, the formation of apical foramen, pathologic radiolucency and calcification of pulp chamber or root canal obliteration.

A smartphone-assisted colorimetric and photothermal probe for glutathione detection based on enhanced oxidase-mimic CoFeCe three-atom nanozyme in food.

The rational fabrication of point-of-care testing (POCT) featuring simplicity, rapidity, low cost, portability, high sensitivity and accuracy is crucial for maintaining food safety in resource-limited locations and home healthcare but remains challenging. Herein, we report a universal colorimetric-photothermal-smartphone triple-mode sensing platform for POC food-grade glutathione (GSH) detection. This simple sensing platform for GSH detection takes merits of three techniques: commercially available filter paper, thermometer and smartphone via an excellent CoFeCe-mediated oxidase-like activity.

Dual-mode biosensor platform based on synergistic effects of dual-functional hybrid nanomaterials.

Detection of biomarkers is very vital in the prevention, diagnosis and treatment of diseases. However, due to the poor accuracy and sensitivity of the constructed biosensors, we are now facing great challenges. In addressing these problems, nanohybrid-based dual mode biosensors including optical-optical, optical-electrochemical and electrochemical-electrochemical have been developed to detect various biomarkers.

Exome sequencing analysis of gastric primary myeloid sarcoma with monocytic differentiation with altered immunophenotype after chemotherapy: case report.

Background: Myeloid Sarcoma with monocytic differentiation is rare and quite likely is missed by surgical pathologists. However it is frequently misdiagnosed because of its non-specific imaging and histological pattern.

Case Presentation: We report the case of a 64-year-old woman with gastric primary myeloid sarcoma with monocytic differentiatio.

Dual-mode biosensing platform for sensitive and portable detection of hydrogen sulfide based on cuprous oxide/gold/copper metal organic framework heterojunction.

Hydrogen sulfide (HS) can not only be regarded as a critical gas signal transduction substance, but also its excess levels can lead to a range of diseases. Currently, the accurate analysis combined with electrochemical (EC) or photothermal (PT) technology for HS in a complex biological system remains a significant challenge. Herein, an endogenous HS-triggered heterojunction cuprous oxide/gold/copper metal organic framework (CuO/Au/HKUST-1) nanoprobe is designed for dual-mode EC- second near-infrared (NIR-II)/PT analysis in tumor cells with high sensitivity and simplicity.

Biosynthesis-mediated Ni-Fe-Cu LDH-to-sulfides transformation enabling sensitive detection of endogenous hydrogen sulfide with dual-readout signals.

Hydrogen sulfide (HS) is a vital endogenous gas signal molecule undertaking numerous physiological functions such as biological regulation and cytoprotection. Herein, we developed an electrochemical (EC) and photothermal (PT) dual-readout signals method for HS detection based on a novel biosynthesis-mediated Ni-Fe-Cu LDH-to-sulfides transformation strategy. Interestingly, the Cu-based Ni-Fe LDH (Ni-Fe-Cu LDH) can act as the Cu source to react with HS, resulting in the in-situ generation of CuS on Ni-Fe-Cu LDH surfaces.

Tumor acidity and near-infrared light responsive drug delivery MoS-based nanoparticles for chemo-photothermal therapy.

The rational design of tumor microenvironment (TME)- multifunctional stimuli-responsive nanocomposites is appealing for effective cancer treatment. However, multidrug resistance remains an obstacle to construct responsive oncotherapy. Herein, a novel MoS/PDA-TPP nanocomposite loaded with chemotherapy drug of doxorubicin (DOX) is designed for TME dual-response and synergistically enhanced anti-tumor therapy based on the tumor-specific mitochondria accumulation ability and photothermal (PTT) therapy.

Metal-organic framework promoting high-solids enzymatic hydrolysis of untreated corncob residues.

Metal-organic frameworks (MOFs) could serve as efficient matrixes to immobilize cellulase because of their high stability and porous morphology. Herein, the Zr-based MOFs (UiO-66 and UiO-66-NH) assisted 20 wt% high-solids hydrolysis of untreated corncob residues (CRs) at low enzyme loading was investigated. Glucan hydrolysis yields increased to 60.

Large-Scale Production of Hierarchically Porous Metal-Organic Frameworks by a Reflux-Assisted Post-Synthetic Ligand Substitution Strategy.

The mass production of hierarchically porous metal-organic frameworks (HP-MOFs) with adjustable morphology and size as well as retained crystallinity is highly desirable yet challenging. Herein, we have developed a versatile post-synthetic ligand substitution (PSLS) strategy to convert typical microporous MOFs and even their composites to HP-MOFs and their composites at a 10 g level and beyond in a simple reflux system. The resulting HP-MOFs feature intrinsic micropores and abundant defective mesopores, which greatly facilitate the transport and activation of large substrates for stable and efficient heterogeneous catalysis.

In situ growth of amino-functionalized ZIF-8 on bacterial cellulose foams for enhanced CO adsorption.

Zeolitic imidazolate frameworks (ZIFs) hold great potential for carbon capture, while a major challenge for the practical application of ZIFs is the development of convenient three-dimensional bulk materials. Here, sustainable and biodegradable bacterial cellulose (BC) was used as the substrate for ZIF growth. Amino-functionalized ZIF-8 (ZIF-8-NH) was prepared within BC substrate via an in situ growth approach.

SR-B1 and CD10 combined immunoprofile for differential diagnosis of metastatic clear cell renal cell carcinoma and clear cell carcinoma of the ovary.

Unlabelled: Both clear cell renal carcinoma (ccRCC) and clear cell carcinoma of the ovary (CCOC) have a clear cytoplasmic morphological feature, hence it is difficult to identify metastatic ccRCC and CCOC by morphology alone. At present, there are no effective immunohistochemical markers to distinguish between these two tumors. Studies have shown that the clear cytoplasm of ccRCC is mainly caused by cholesterol-rich lipids in the cytoplasm, while that of CCOC is due to the accumulation of cytoplasmic glycogen.

Comparison of indirect pulp treatment and iRoot BP Plus pulpotomy in primary teeth with extremely deep caries: a prospective randomized trial.

Objectives: The purpose of this randomized controlled trial was to compare the 24-month success rates of indirect pulp treatment (IPT) and iRoot BP Plus pulpotomy of primary molars with extremely deep caries.

Materials And Methods: Generally healthy children aged 3-7 years requiring general anesthesia for treating primary molars with extremely deep caries or reversible pulpitis were recruited. Patients with systemic disease, mental health problems, or manifestations of irreversible pulpitis were excluded.

Facial Morphological Changes Following Denture Treatment in Children with Hypohidrotic Ectodermal Dysplasia.

The purpose of this study was to characterize the facial morphology of Chinese children with hypohidrotic ectodermal dysplasia (HED) and quantify facial changes after prosthetic treatment. 3-D facial images of 12 HED children were taken and their facial morphology was compared against 28 healthy controls. Facial changes due to denture placement were also quantified.

Improving MOF stability: approaches and applications.

Metal-organic frameworks (MOFs) have been recognized as one of the most important classes of porous materials due to their unique attributes and chemical versatility. Unfortunately, some MOFs suffer from the drawback of relatively poor stability, which would limit their practical applications. In the recent past, great efforts have been invested in developing strategies to improve the stability of MOFs.

MicroRNA-31 weakens cisplatin resistance of medulloblastoma cells via NF-κB and PI3K/AKT pathways.

Background: Medulloblastoma (MB) is a malignant intracranial tumor. Cisplatin is a broad-spectrum antitumor drug. It is important to study the cisplatin resistance of MB cells for the treatment of MB.

Encapsulating soluble active species into hollow crystalline porous capsules beyond integration of homogeneous and heterogeneous catalysis.

Homogeneous molecular catalysts and heterogeneous catalysts possess complementary strengths, and are of great importance in laboratory/commercial procedures. While various porous hosts, such as polymers, carbons, silica, metal oxides and zeolites, have been used in an attempt to heterogenize homogeneous catalysts, realizing the integration of both functions at the expense of discounting their respective advantages, it remains a significant challenge to truly combine their intrinsic strengths in a single catalyst without compromise. Here, we describe a general template-assisted approach to incorporating soluble molecular catalysts into the hollow porous capsule, which prevents their leaching due to the absence of large intergranular space.

Carbon capture and conversion using metal-organic frameworks and MOF-based materials.

Rapidly increasing atmospheric CO2 concentrations threaten human society, the natural environment, and the synergy between the two. In order to ameliorate the CO2 problem, carbon capture and conversion techniques have been proposed. Metal-organic framework (MOF)-based materials, a relatively new class of porous materials with unique structural features, high surface areas, chemical tunability and stability, have been extensively studied with respect to their applicability to such techniques.

Comparative analysis of gene expression profiles in children with type 1 diabetes mellitus.

Type 1 diabetes (T1D) is an autoimmune disease that is typically diagnosed in children. The aim of the present study was to identify potential genes involved in the pathogenesis of childhood T1D. Two datasets of mRNA expression in children with T1D were obtained from the Gene Expression Omnibus (GEO).

Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.

Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant and possesses neuroprotective effects. Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis and synaptic plasticity. In this study, we aimed to assess the protective effects of EGCG against sevoflurane-induced neurotoxicity in neonatal mice.