Molecular Genetic Study on HAND2 Gene Promoter in Ventricular Septal Defect.

Ventricular septal defect (VSD), the most common type of congenital heart disease (CHD), is primarily caused by cardiac dysplasia. Heart and neural crest derivatives expressed 2 (HAND2) participates in developing the right heart. The loss of HAND2 expression in humans is closely connected with ventricular septal defects.

Passive Beamforming Design of IRS-Assisted MIMO Systems Based on Deep Learning.

In the intelligent reflecting surface (IRS)-assisted MIMO systems, optimizing the passive beamforming of the IRS to maximize spectral efficiency is crucial. However, due to the unit-modulus constraint of the IRS, the design of an optimal passive beamforming solution becomes a challenging task. The feature input of existing schemes often neglects to exploit channel state information (CSI), and all input data are treated equally in the network, which cannot effectively pay attention to the key information and features in the input.

[Association of ventricular septal defect with rare variations of the gene].

Objectives: To study the association of ventricular septal defect (VSD) with rare variations in the promoter region of gene, as well as related molecular mechanisms.

Methods: Blood samples were collected from 349 children with VSD and 345 healthy controls. The target fragments were amplified by polymerase chain reaction and sequenced to identify the rare variation sites in the promoter region of the gene.