Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses.

Dihydromaniwamycin E (), a new maniwamycin derivative featuring an azoxy moiety, has been isolated from the culture extract of thermotolerant sp. JA74 along with the known analogue maniwamycin E (). Compound is produced only by cultivation of strain JA74 at 45 °C, and this type of compound has been previously designated a "heat shock metabolite (HSM)" by our research group.