Publications by authors named "Meike Kloster-Landsberg"
Article Synopsis
- Heat shock factor 1 (HSF1) is crucial for the heat shock response, helping protect cells from stress by binding to and activating heat shock protein (hsp) genes and satellite III sequences.
- During stress, HSF1 forms nuclear stress bodies (nSBs) which enhance transcription sites, showcasing its role in managing cellular responses.
- The study uses advanced microscopy techniques to reveal that HSF1 interacts with DNA in two ways: through specific binding to Heat Shock Elements and satellite sequences, and through more transient interactions, with the trimerization domain being essential for low-affinity chromatin binding.
Heat shock triggers a transient and ubiquitous response, the function of which is to protect cells against stress-induced damage. The heat-shock response is controlled by a key transcription factor known as heat shock factor 1 (HSF1). We have developed a multiconfocal fluorescence correlation spectroscopy setup to measure the dynamics of HSF1 during the course of the heat-shock response.
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