Association between leisure-time physical activity and incident cancer risk: a nationwide population-based cohort study.

Background: The effects of physical activity on the development of different types of cancers have not been comprehensively studied. This nationwide, population-based cohort study investigated the effects of leisure-time physical activity (LTPA) on the development of different types of cancer in Taiwanese adults. A total of 67,890 adult participants (≥ 18 y old) from five rounds (2001, 2005, 2009, 2013, and 2017) of the Taiwan National Health Interview Survey were included.

Impact of COVID-19 Pandemic on the Prevalence of Metabolic Syndrome in Health Care Workers: A Cohort Study at a Designated COVID-19 Hospital in Taiwan.

Objectives: This cohort study aimed to determine the effect of the COVID-19 pandemic on the prevalence of metabolic syndrome (MetS) among health care workers at a dedicated COVID-19 hospital in Taiwan.

Methods: This study recruited 397 health care workers who completed health checkups before and during the COVID-19 pandemic. The differences of MetS and its components prevalence before and during the COVID-19 pandemic were compared using the paired samples t tests for normally distributed variables, and Wilcoxon signed-rank tests for nonnormally distributed variables.

Modification of Risk for All-Cause and Cardiovascular Disease-Related Mortality with Changes in the Body Mass Index in Older Individuals: A Population-Based Cohort Study.

Introduction: Existing evidence evaluating the impact of change in body mass index (BMI) on the risk of all-cause and cardiovascular disease (CVD)-related mortality in older people is limited and inconsistent. This population-based cohort study evaluated the association of changes in BMI over time with all-cause and CVD-related mortality in older adults.

Methods: We recruited 55,351 adults aged over 65 years between 2006 and 2011 from Taipei Elderly Health Examination Program who underwent repeated annual health examinations at 3.

New-onset Glaucoma Following Moderna COVID-19 Vaccination.

Aim: To report a case of new-onset glaucoma following administration of the Moderna (mRNA-1273) vaccine.

Background: Previous studies have reported a low incidence of ocular adverse events induced by the coronavirus disease 2019 (COVID-19) vaccine. The literature on open-angle glaucoma associated with COVID-19 vaccination is limited.

Surface charge regulation of imidazolium salts/starch/carboxymethyl cellulose ternary polymer blend films for controlling antimicrobial performance and hydrophobicity.

Starch (SR)/carboxymethyl cellulose (CMC) based antimicrobial films have been widely applied in packaging field. As a high-effect antimicrobial agent, the surface charge of imidazolium salt plays an important effect on antimicrobial performances of starch/carboxymethyl cellulose. Here in, the surface charge of dodecyl imidazolium bromide salt was regulated via thiol-ene reaction.

Effects of safety attitude on factors related to burnout among nurses working at a dedicated infectious disease control hospital during the COVID-19 pandemic.

Aim: Repeated occupational exposure and increased stress and fatigue levels contribute to a high risk of coronavirus disease 2019 (COVID-19) infection among frontline nurses. This study aimed to explore the relationships among teamwork, work environment and resources, work-life balance, stress perception and burnout among nurses working at a dedicated infectious disease control hospital.

Methods: The participants were 389 nurses at a dedicated infectious disease control hospital in Taipei City, Taiwan.

Construct of CoZnO/CSP biomass-derived carbon composites with broad effective absorption bandwidth of 7.2 GHz and excellent microwave absorption performance.

Biomass-carbon materials have excellent electromagnetic wave attenuation properties, which is one of the essential factors for developing ultra-thin matched-thickness, and high-performance microwave absorption materials. This study reports a two-step procedure consisting of carbonization and subsequent in-situ growth for preparing a wrinkle-like multilayer biomass-derived composites with magnetic Co particles and ZnO particles (CoZnO/C-X). The synergistic effect of a wrinkle-like multilayer structure and Co and ZnO particles, as well as the existence of many heterogeneous interfaces in the composites structure, and efficiently creates multiple scattering and reflections, which gives the composites the strong microwave absorption properties.

Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma.

Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many patients show resistance. Here we perform integrative transcriptomic and proteomic analyses on emerging immuno-oncology targets across multiple clinical cohorts of melanoma under anti-PD-1 treatment, on both bulk and single-cell levels. We reveal a surprising role of tumor-intrinsic SIRPA in enhancing antitumor immunity, in contrast to its well-established role as a major inhibitory immune modulator in macrophages.

Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021.

Background: To investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy.

Methods: We reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital. We recorded the demographic and clinical characteristics of patients before, during and after surgery.

Structural optimization and antibacterial property of alkylimidazole salt/carboxymethyl cellulose/starch composite films.

As a green solvent, alkylimidazolium salt has attracted much attention due to high antibacterial activity and excellent biocompatibility. In this work, 1-allyl-3-alkylimidazolium bromide ionic liquids (AIMB) were synthesized in a closed system. Using carboxymethyl cellulose (CMC) and starch (SR) as carriers, 1-allyl-3-dodecylimidazolium bromide ionic liquid (AIMC12)/CMC/SR (AIMCS) films were prepared via solution casting method.

Risk factors for ocular neovascularization after central retinal artery occlusion.

Background: To report the incidence and risk factors associated with ocular neovascularization (NV) in patients with central retinal artery occlusion (CRAO).

Methods: This retrospective study included patients diagnosed with acute CRAO in a single tertiary center. Medical charts were reviewed for ocular NV occurrences.

A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.

The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer, primarily hepatocellular carcinoma (HCC), is highly lethal with limited treatment options. LIFR is frequently downregulated in HCC.

A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma.

Cutaneous melanoma is the most malignant skin cancer. Biomarkers for stratifying patients at initial diagnosis and informing clinical decisions are highly sought after. Here we classified melanoma patients into three immune subtypes by single-sample gene-set enrichment analysis.

Normal tension glaucoma in Asia: Epidemiology, pathogenesis, diagnosis, and management.

Normal tension glaucoma (NTG) has similar optic neuropathy as primary open-angle glaucoma (POAG), but intraocular pressure (IOP) is within the normal range. Compared with high-pressure POAG, the development of NTG is possibly a consequence of a complex interaction of several ocular and systemic factors. Recent data have shown higher translaminar pressure gradient due to impaired cerebrospinal fluid dynamics may account for the pathogenic mechanism.