Theoretical Investigation of Two-Dimensional FeC Structures with Surface Van Hove Singularity for Electrochemical Nitric Oxide Reduction Reaction.

The electrochemical nitric oxide reduction reaction (eNORR) is an efficient method for converting aqueous NO into NH. The pursuit of innovative electrocatalysts with enhanced activity, selectivity, durability, and cost-effectiveness for NORR remains a research focus. In this study, using particle swarm optimization (PSO) searches, density functional theory (DFT), and the constant-potential method (CPM), we predict two stable two-dimensional FeC monolayers, designated as α-FeC and β-FeC, as promising electrocatalysts for the NORR.

Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells.

Erk signaling is indispensable for the self-renewal and differentiation of mouse embryonic stem cells (ESCs), as well as telomere homeostasis. But how Erk regulates these biological processes remains unclear. We identified 132 Erk2 interacting proteins by co-immunoprecipitation and mass spectrometric analysis, and focused on Ddx39 as a potential Erk2 substrate.

2D-MnC: An Optimal Electrocatalyst with Nonbonding Multiple Single Centers for CO-to-CH Conversion.

The CO reduction reaction (CORR) is a promising method that can both mitigate the greenhouse effect and generate valuable chemicals. The 2D-MC with high-density transition metal single atoms is a potential catalyst for various catalytic reactions. Using an effective strategy, we screened 1s-MnC as the most promising electrocatalyst for the CORR in the newly reported 2D-MC family.

CCR2 monocytes replenish border-associated macrophages in the diseased mouse brain.

Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from yolk sac progenitors that do not persist after birth, the means by which this population of cells is maintained is not well understood. Using two-photon microscopy and multiple lineage-tracing strategies, we determine that CCR2 monocytes are significant contributors to BAM populations following disruptions of CNS homeostasis in adult mice.

A Novel Peptide COX Inhibits High Glucose-induced Insulin Secretion by Modulating BK Channel Activity.

Background: Excessive insulin is the leading cause of metabolic syndromes besides hyperinsulinemia. Insulin-lowering therapeutic peptides have been poorly studied and warrant urgent attention.

Objectives: The main purpose of this study, was to introduce a novel peptide COX that was initially isolated from the porcine small intestine and possessed the ability to inhibit insulin secretion under high-glucose conditions by modulating large conductance Ca-activated K channels (BK channels) activity.

Cementum protein 1 gene-modified adipose-derived mesenchymal stem cell sheets enhance periodontal regeneration in osteoporosis rat.

Background And Objectives: Osteoporosis (OP) and periodontitis are both diseases with excessive bone resorption, and the number of patients who suffer from these diseases is expected to increase. OP has been identified as a risk factor that accelerates the pathological process of periodontitis. Achieving effective and safe periodontal regeneration in OP patients is a meaningful challenge.

Antimicrobial diterpenoids from the leaves and twigs of Croton kongensis Gagnepain.

Croton kongensis Gagnepain. belongs to the genus Croton, the Euphorbiaceae family, mainly distributed in Hainan and southern Yunnan, China. The aim of present study was to acquire secondary metabolites of the ethanol extract obtained from the leaves and twigs of C.

Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels.

Salvia has been regarded as a beneficial healing herb in ancient Egypt, Rome and Greece, and is listed as an official medicine in the pharmacopoeias of many countries worldwide. Currently, Salvia is widely used to flavor and preserve food. Here, two undescribed norabietane-type diterpenoids, sadigitaloides A and B, two undescribed germacrane-type sesquiterpenoids, sadigitaloides C and D, five undescribed guaiane-type sesquiterpenoid lactones, sadigitaloides E-I, two undescribed noreudesmane-type sesquiterpenoids, sadigitaloides J and K, one known diterpenoid, three known sesquiterpenoids, and three other types of known compounds were isolated from the 95% ethanol extract of the whole plants of Salvia digitaloides.

A new diterpenoid from the leaves and twigs of Benth.

A new clerodane diterpenoid, crotolanin A (), along with three known clerodane diterpenoids, crotoeurin B (), teucvidin () and teucvin (), was isolated from the ethanol extract of the leaves and twigs of Benth. Their structures were identified by extensive NMR spectroscopic and HRESIMS analyses. The dopaminergic neuroprotective activity of compounds - was tested by using transgenic pathological model.

Caesalpinbondin A, a Novel Diterpenoid Lactone With an Unprecedented Carbon Skeleton from the Seeds of .

One novel diterpenoid lactone named caesalpinbondin A () that possesses an unprecedented tetracyclic ring system in which a 6/6/5-fused tricyclic ring and a 4,5-dimethyldihydrofuran-2(3H)-one were connected by a C-C single bond comprising a 5-(naphtho [2,3-b]furan-7-yl)dihydrofuran-2(3H)-one moiety was isolated from the seeds of . Its chemical structure was established by extensive spectroscopic methods, and its absolute configuration was further determined by single-crystal X-ray diffraction analysis and electronic circular dichroism calculation. The biological evaluation suggested that compound demonstrated potent anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD .

Diterpenoids with α-glucosidase inhibitory activities from the fruits of Vitex trifolia Linn.

Viticis Fructus, known as "Man-jing-zi", are the fruits of the traditional Chinese medicine Vitex trifolia Linn. and its variant Vitex trifolia Linn. var.

CD155 promotes radioresistance and malignancy of esophageal cancer by regulating Hippo-YAP pathway.

The expression of CD155 has been observed to increase in various human cancers, but its role in the development of esophageal cancer (EC) is unclear. Radiotherapy is one of the primary therapeutic options for EC. However, radioresistance is still a severe issue in EC treatment.

SPP1 promotes radiation resistance through JAK2/STAT3 pathway in esophageal carcinoma.

Background: Therapeutic resistance to radiotherapy is one of the major obstacles in clinical practice that significantly affect the therapeutic efficiency and prognosis of human esophageal carcinoma (ESCA). Thus, it is critical to understand the molecular mechanisms of radiation resistance in ESCA. Secreted phosphoprotein 1 (SPP1) plays an essential role in various human cancers, but its role in radiation resistance remains unclear.

Diterpenoids and C Nor-Isoprenoid Identified From the Leaves and Twigs of Activating Apoptosis and Pyroptosis.

(Family Euphorbiaceae) is an annual aromatic plant endemic to Yunnan Province, China, which yields an aromatic, spicy oil used as a flavoring and fragrance. The aim of the present study was to acquire secondary metabolites from the leaves and twigs of and to evaluate their cytotoxic activity. Five new diterpenoids, croyanhuins A-E (-), and one new C nor-isoprenoid, croyanhuin F (), were isolated from the leaves and twigs of .

Repeatability of i.Profiler for measuring wavefront aberrations in healthy eyes.

Purpose: To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.Profiler; Carl Zeiss Vision, Germany).

Methods: A prospective cross-sectional study.

Nurses' voice behaviour: The influence of humble leadership, affective commitment and job embeddedness in China.

Aim: To test the influence of humble leadership, job embeddedness and affective commitment on the voice behaviour of nurses.

Background: A nurse's voice behaviour is regarded as an important measure to identify and solve problems in medical institutions, and improve patients' satisfaction. It is urgent to pay sufficient attention to nurses' advice to determine which factors can stimulate enthusiasm in this area.

Dynamics of TRF1 organizing a single human telomere.

Chromosome stability is primarily determined by telomere length. TRF1 is the core subunit of shelterin that plays a critical role in telomere organization and replication. However, the dynamics of TRF1 in scenarios of telomere-processing activities remain elusive.

Analysis of conference abstracts of prosthodontic randomised-controlled trials presented at IADR general sessions (2002-2015): a cross-sectional study of the relationship between demographic characteristics, reporting quality and final publication.

Objectives: To analyse the relationship between demographic characteristics, reporting quality and final publication rate of conference abstracts of prosthodontic randomised-controlled trials (RCTs) presented at International Association for Dental Research (IADR) general sessions (2002-2015).

Design: A cross-sectional study on conference abstracts.

Methods: Conference abstracts of prosthodontic RCTs presented at IADR general sessions (2002-2015) were obtained.

Dual pH-responsive charge-reversal and photo-crosslinkable polymer nanoparticles for controlled drug release.

In this article, we introduce a pH-responsive charge-reversible and photo-crosslinkable polymer nanoparticle. It is prepared typical self-assembly from a block copolymer poly((7-(4-vinyl-benzyloxyl)-4-methylcoumarin)-co-acrylicacid)-b-poly((2-dimethylamino) ethyl methacrylate)-co-styrene) (P(VBMC-co-AA)-b-P(DMAEMA-co-St)), whose two blocks have different ionizable moieties. In an aqueous solution of pH ≤ 4, the cationic polymer nanoparticles are formed due to the fully protonated PDMAEMA.

The Impact of Inclusive Leadership on Employees' Innovative Behaviors: The Mediation of Psychological Capital.

Employee innovation is the cornerstone of the organization, and the motivation for employee innovative behavior largely depends on the leadership style of the leader. With the economic development of society, the traditional authoritative style of leadership can no longer adapt to the psychological characteristics of employees, who use new-era work concepts, techniques, and social rules (hereafter, new generation employees). Inclusive leadership is based on the concept of "fully inclusive and equitable" in traditional Chinese culture, and it can adapt to the independent needs of new generation employees.

The risk of moderate-to-severe post-operative pain following the placement of dental implants.

In recent years, the implant-supported dentures have risen rapidly, and thus, more attention was paid to post-operative pain, following dental implantation. To explore risk factors and establish as well as validate a risk prediction model for moderate-to-severe post-operative pain following dental implantation. A observational study of 352 patients with 563 implants was carried out.

Dynamic changes of peri-implant soft tissue after interim restoration removal during a digital intraoral scan.

Statement Of Problem: During a digital intraoral scan for an esthetic implant restoration, the peri-implant soft tissue will collapse rapidly after the interim restoration (IR) is removed, making it difficult to replicate the established emergence profile. The rate of this collapse is unclear.

Purpose: The purpose of this clinical study was to determine whether significant dimension differences could be found between peri-implant soft tissue supported by an IR and that immediately after removal of the restoration and to assess the changes over time.

Fabrication of high-capacity polyelectrolyte brush-grafted porous AAO-silica composite membrane via RAFT polymerization.

Surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization has been utilized to fabricate high-capacity strong anion-exchange (AEX) membrane for the separation of protein. By means of RAFT polymerization, quaternized poly(3-(methacrylamidomethyl)-pyridine) brushes formed 3-dimensional nanolayers on the surface of porous anodic aluminum oxide (AAO)-silica composite membrane. The surface properties of the membranes were analyzed by SEM, water contact angle, ATR-FTIR, XPS and TGA.

miR-320a regulates high mobility group box 1 expression and inhibits invasion and metastasis in hepatocellular carcinoma.

Background & Aims: Several studies have shown that miR-320a induces apoptosis, inhibits cell proliferation, and affects cell cycle progression as a tumour suppressor in many cancers. However, the involvement of miR-320a in the invasion and metastasis of hepatocellular carcinoma (HCC) is still unknown.

Methods: Endogenous miR-320a and high mobility group box 1 (HMGB1) expressions were assayed by real-time PCR.

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.

Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules that also activate different intracellular signalling pathways. Here we reveal that TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), stimulates acute catecholamine secretion through coupling with the transient receptor potential cation channel subfamily C 3 (TRPC3).