Publications by authors named "Meihong Yan"
Article Synopsis
- Breast cancer (BC), particularly the ductal subtype, shows significant cellular diversity which affects treatment outcomes; this study uses single-cell RNA sequencing data to explore this heterogeneity and identify potential markers for prognosis and therapy.
- Bioinformatics methods were applied to analyze single-cell sequencing data, highlighting differences in gene expression and behavior between Type 1 and Type 2 ductal epithelial cells, along with identifying key genes (CYP24A1 and TFPI2) linked to patient prognosis.
- The findings underscore the importance of cellular heterogeneity in ductal BC, revealing CYP24A1 and TFPI2 as significant prognostic markers and therapeutic targets, with validation showing their role in inhibiting malignant behaviors in BC cells.
Theanine is a unique secondary metabolite in tea plants and contributes to the umami taste and health benefits of tea. However, theanine biosynthesis in tea plants is not fully understood, and its mechanism of transcriptional regulation remains poorly reported. Theanine content was significantly correlated with the expression of theanine biosynthesis-related gene CsGS1c and transcription factor CsMYB42 in different leaf positions and picking times, but there was no significant correlation in different tissues of albino tea plant 'Anjibaicha'.
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