Exosomes-mediated transfer of LINC00691 regulates the formation of CAFs and promotes the progression of gastric cancer.

Objective: Gastric cancer (GC) is one of the malignant tumors with the highest mortality worldwide. Our previous studies have revealed that LINC00691 is up-regulated in serum of GC patients as a novel potential biomarker for GC diagnosis and prognosis. However, the roles of serum exosomal LINC00691 in GC has not been clarified.

Antinuclear antibodies in healthy population: Positive association with abnormal tissue metabolism, inflammation and immune dysfunction.

Antinuclear antibodies (ANAs) are a spectrum of autoantibodies that react with cell nucleus structures. ANA assay is a screening test for the diagnosis of autoimmune disease. Although many patients with positive ANA did not develop autoimmune diseases, it is unclear whether high concentrations of ANA have potential damage to the body.

Drug-Induced Liver Disturbance During the Treatment of COVID-19.

An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, China, at the end of 2019. The World Health Organization named the resulting infectious disease as coronavirus disease-2019 (COVID-19). Many studies concluded that patients infected with SARS-CoV-2 have different degrees of liver disturbance.

Immunological Manifestations of Hepatitis E-Associated Acute and Chronic Liver Failure and Its Regulatory Mechanisms.

Hepatitis E virus (HEV) is a common cause of viral hepatitis in developing countries, most commonly transmitted through the fecal-oral route. The virus is mainly of genotypes (GT) 1 and GT2 genotypes, and patients usually show symptoms of acute hepatitis. Due to the rising trend of HEV serological prevalence in global population, HEV has become an important public health problem in developed countries.

Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway.

Our previous research demonstrated that compound licochalcone E can reduce glucose tolerance and lipid metabolism in diabetic rats, although its mechanism remains unknown. Here, we used palmitic acid (PA) to establish a PA-treated HepG2 model, and then examined glucose uptake, glucose consumption, and blood lipids to evaluate the effects of licochalcone E within the safe dose range in the model. Polymerase chain reaction (PCR) was used to detect the expression levels of key genes associated with liver gluconeogenesis; enzyme-linked immunosorbent assay (ELISA) was deployed to evaluate the concentration of inflammatory factors; and laser confocal microscopy and western blot were used to determine the levels of reactive oxygen species (ROS) and NLRP3 inflammasome signaling pathway-related proteins, respectively.

Enhanced LINC01061 Levels as a Serum Biomarker in Gastric Cancer and Promotion of Malignant Transformation.

Background: The genomic copy number of LINC01061 is amplified in papillary thyroid cancer. However, its role in gastric cancer is not clear.

Materials And Methods: Tissues and serum of GC patients were collected to detect the expression of LINC01061 by quantitative real-time polymerase chain reaction (qRT-PCR).

Overexpression of LINC00691 promotes the proliferation and invasion of gastric cancer cells via the Janus kinase/signal transducer and activator of transcription signalling pathway.

This report aims to explore how LINC00691 regulates the proliferation and invasion of gastric cancer (GC). Clinical tissue and serum samples, as well as specimens in the Cancer Genome Atlas (TCGA) database, were used to analyse the expression of LINC00691 in GC. Our data indicated that the expression of LINC00691 in GC was significantly higher than that in healthy controls and was associated with clinicopathological features and survival time.

A novel plasma lncRNA ENST00000416361 is upregulated in coronary artery disease and is related to inflammation and lipid metabolism.

Coronary artery disease (CAD) is a serious threat to human health and a major cause of mortality worldwide. Long noncoding RNAs (lncRNAs) affect the occurrence and development of CAD via the regulation of cell proliferation and apoptosis, inflammatory responses and lipid metabolism. Screening methods and therapeutic strategies for CAD have been extensively studied.

Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients.

Crohn disease (CD) is a multifactorial autoimmune disease which is characterized by chronic and recurrent gastrointestinal tract inflammatory disorder. However, the molecular mechanisms of CD remain unclear. Increasing evidences have demonstrated that circular RNAs (circRNAs) participate in the pathogenesis of a variety of disease and were considered as ideal biomarkers in human disease.

Direct imaging of a single Ni atom cutting graphene to form a graphene nanomesh.

A large area graphene nanomesh (GNM) etched by Ni is synthesized by a facile one-step liquid arc discharge in a Ni-containing solution. Atomic-resolution scanning transmission electron microscopy (STEM) combined with electron energy loss spectroscopy (EELS) is applied to identify the atomic structures of the product. The results show that the GNM with a pore size of about 10-50 nm comprises single- or few layer graphene, and there are some small pores of size 1 nm and defects of five membered rings or seven membered rings in the positions of the skeletons.

ATF3 and PRAP1 play important roles in cisplatin-induced damages in microvascular endothelial cells.

Background: The early intervention is a rational approach to reduce the cardiovascular disease mortality in cancer patients. Here, we tried to identify potential biomarkers for the endothelial damage caused by cisplatin, a typical chemotherapy compound, and explore its underlying mechanisms.

Methods: Microarray dataset GSE62523 were utilized to assess the gene differential expression from human micro-vascular endothelial cells (HMEC-1) treated with cisplatin.

Direct imaging of construction of carbon onions by curling few-layer graphene flakes.

The violent reaction processing and required high-temperature environment involved in growing carbon onions make it difficult to obtain an insight into their evolution mechanism. By using deionized water as the medium of arc discharge, we successfully froze the synthetic reaction at intermediary stages and observed detailed structures of the obtained intermediates of carbon onions. Here we present the atomic-scale scanning transmission electron microscopy investigation of carbon onions produced by arc discharge in water.

APOA5 -1131T/C polymorphism is associated with coronary artery disease in a Chinese population: a meta-analysis.

Background: Functional studies suggest that the APOA5 -1131T/C polymorphism plays an important role in triglyceride (TG) metabolism, which is an event contributing to the pathogenesis of coronary artery disease (CAD). However, genetic evidence of its effect on CAD is inconsistent. To assess this correlation, we performed a meta-analysis of published data.

[Raman spectroscopic characteristics of different rank coals and the relation with XRD structural parameters].

The Raman spectroscopic analysis for eleven different rank coals (57.58% to 94.01% of Cdaf, %) indicated that two distinct bands, i.