Identification of angiogenesis-related subtypes and risk models for predicting the prognosis of gastric cancer patients.

Gastric cancer (GC) is a leading cause of cancer-related mortality and is characterized by significant heterogeneity, highlighting the need for further studies aimed at personalized treatment strategies. Tumor angiogenesis is critical for tumor development and metastasis, yet its role in molecular subtyping and prognosis prediction remains underexplored. This study aims to identify angiogenesis-related subtypes and develop a prognostic model for GC patients.

Prevalences of metabolic syndrome and its sex-specific association with socioeconomic status in rural China: a cross-sectional study.

Background: Few studies have reported the prevalence of metabolic syndrome (MS) and examined relationships between socioeconomic status and MS in rural China. This study aimed to evaluate the prevalence of MS and MS components as well as their associations with socioeconomic status among rural Chinese adults.

Methods: A cross-sectional study of 26,836 participants aged 20 years and older was conducted from June to December 2012 in Yuhuan City, Zhejiang Province, China, which is located on Yuhuan Island.

Associations Between Thyroid Volume and Physical Growth in Pubertal Girls: Thyroid Volume Indexes Need to Be Applied to Thyroid Volume Assessments.

Background: Thyroid volume (Tvol) is associated with many factors, but the current reference values for Tvol in children with sufficient iodine intake are inappropriate and need to be updated. Moderate changes in thyroid morphology and accentuated increases in body fat percentage occur during puberty as an adaption of the body and sexual development occurs. This study aimed to evaluate the influences of physical growth on Tvol and propose an easily applicable method for conducting Tvol assessments in pubertal girls with sufficient iodine intake.

Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China.

Background: The onset of puberty is influenced by thyroid function, and thyroid hormones (THs) fluctuate substantially during the period of pubertal development. However, it needs to be further clarified how THs change at specific puberty stages and how it influences pubertal development in girls. So far, longitudinal data from China are scarce.

Thyroid Stimulating Hormone (TSH) Is Associated With General and Abdominal Obesity: A Cohort Study in School-Aged Girls During Puberty in East China.

Although the association between thyroid stimulating hormone (TSH) and obesity in children has been investigated in several cross-sectional studies, no study evaluated this association among girls during puberty, which were in a key period closely related to the fluctuations of thyroid hormones and development of obesity. Therefore, we conducted a cohort study to investigate the association of general and abdominal obesity with TSH in girls during puberty. A cohort study of 481 school-aged girls during puberty was conducted in four regions in east China, with a baseline survey in 2017 and a follow-up survey in 2019.

Enriched taxa were found among the gut microbiota of centenarians in East China.

Background: Gut microbiota is closely related to age. Studies from Europe and the U.S.

[Related factors for early-onset type 2 diabetes mellitus of rural adults in Yuhuan County of Zhejiang Province in 2012].

Objective: To explore related factors for early-onset type 2 diabetes mellitus( EOD) in rural Chinese adults.

Methods: Totally, 1695 newly diagnosed cases of type 2 diabetes mellitus( T2DM) were recruited from baseline survey of Yuhuan Rural Adults Cohort for Diabetes during June to December 2012 in Yuhuan County, Zhejiang Province, China, and divided into EOD or late-onset type 2 diabetes mellitus( LOD) with their diagnosis age at ≤ 40 or > 40 years, respectively. Diagnosis age was compared among different characteristics.

UCP2 and UCP3 variants and gene-environment interaction associated with prediabetes and T2DM in a rural population: a case control study in China.

Background: There are disparities for the association between uncoupling proteins (UCP) and type 2 diabetes (T2DM). The study was to examine the associations of genetic variants of UCP2 and UCP3 with prediabetes and T2DM in a rural Chinese population.

Methods: A population-based case-control study of 397 adults with T2DM, 394 with prediabetes and 409 with normal glucose tolerance (NGT) was carried out in 2014 in a rural community in eastern China.

Associations of adiposity measurements with thyroid nodules in Chinese children living in iodine-sufficient areas: an observational study.

Objectives: Obesity has been found to be associated with an elevated risk of thyroid nodule(s), mainly in adults; however, evidence for this association in children was limited. The objective of this study was to investigate the association of adiposity and thyroid nodule(s) in children living in iodine-sufficiency areas.

Setting And Participants: We conducted a cross-sectional study of 1403 Chinese children living in the East Coast of China in 2014.

Urinary Antibiotics of Pregnant Women in Eastern China and Cumulative Health Risk Assessment.

Exposure to antibiotics during pregnancy can pose a systematic effect on human health. A few biomonitoring studies have demonstrated an extensive exposure of children to antibiotics, but there is still a lack of data for pregnant women. To assess the exposure of pregnant women to antibiotics and potential health risk, we investigated 536 pregnant women aged 16-42 years from two geographically different study sites in Eastern China in 2015.

[Repeated cross-sectional studies on urinary iodine and iodine content of salt among school-aged children from 2012 to 2014 in Yuhuan County, Zhejiang Province].

Objective: To investigate the iodine status and its change among school-aged children in their morning urine and eating salt from 2012 to 2014 in Yuhuan County, Zhejiang Province, China.

Methods: Three repeated cross-sectional studies were carried out at a same primary school in 2012, 2013 and 2014, respectively. Three classes were randomly selected from each of 3 to 5 grade by the cluster-stratified sampling every year.

[Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes].

Objective: To assess the possible role of insulin resistance (IR) and β cell function in the pathophysiology of newly diagnosed type 2 diabetics (T2DM).

Methods: An oral glucose tolerance test was obtained at the health cohort baseline. Subjects with normal glucose tolerance (NGT, n = 269), impaired glucose regulation (IGR, n = 269) and newly diagnosed type 2 diabetics (T2DM, n = 269) were defined by ADA criteria.

Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children.

Background: Although several studies have evaluated the relationship between bisphenol A (BPA) and thyroid functions, their results are not entirely consistent. Little is known about BPA in relation to thyroid volume and structure.

Methods: We examined the association of BPA with thyroid volume and thyroid nodules using data from 718 Chinese children living in the East Coast of China in 2012.

Antibiotic body burden of Chinese school children: a multisite biomonitoring-based study.

To explore the antibiotic body burden of Chinese school children, total urinary concentrations (free and conjugated) of 18 representative antibiotics (5 macrolides, 2 β-lactams, 3 tetracyclines, 4 quinolones, and 4 sulfonamides) were measured by ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry among 1064 school students recruited from 3 economically and geographically distinct areas in east China in 2013. All 18 antibiotics were detected in urine samples with the detection frequencies ranging from 0.4 to 19.

[Prevalence of hyperglycemia and related factors among rural adults aged 35 years old and above in Yuhuan County, Zhejiang Province].

Objective: To describe the prevalence of hyperglycemia among rural adults aged 35 years old and above in Yuhuan, China.

Method: A cross-sectional study was carried out as a baseline study of Rural Yuhuan Health Population Cohort in all communities in Yuhuan County, Zhejiang Province, China. A total of 125 479 subjects aged 35 years old or above participated in this study to collect the general demographics and measure hypertension, fast glucose and etc.

[A cross-sectional study on urinary iodine and iodine content of salt among school children aged 8-10 years old in Yuhuan County, Zhejiang Province in 2012].

Objective: To understand the level of urinary iodine and iodine content of salt among school children aged 8 to 10 years in Yuhuan County, Zhejiang Province.

Methods: A cross-sectional study was conducted in a primary school of Yuhuan County purposely selected in 2012. Totally, 450 children aged 8 to 10 years were involved by the cluster-stratified sampling.

[Prevalence of hyperlipidemia and possible risk factors in rural Chinese adults: cohort study of health population in Yuhuan rural].

Objective: To examine the prevalence of hyperlipidemia and its related factors in adults in rural Yuhuan, China.

Methods: A cross-sectional study was carried out as a baseline study of Rural Yuhuan Health Population Cohort in all communities in Yuhuan County, Zhejiang Province, China. A total of 118,571 subjects aged 35 years old or above participated in this study.

[Evaluation on the efficacy of recombinant hepatitis B vaccine booster immunization in 2789 children aged over 10 years].

Objective: To study the efficiency of booster immunization with different recombinant hepatitis B vaccines.

Methods: 2789 children aged over 10 years who had completed the basic immunization of hepatitis B vaccine under 1 year old were selected. All the sampled children were classified into four groups (A, B, C and D) and immunized with different hepatitis B vaccines produced by different companies respectively.

Herpes simplex virus infections among rural residents in eastern China.

Background: Herpes simplex virus (HSV) has two types: HSV-1 and HSV-2. Both infect epithelial cells and establish latent infections in neurons causing an infection that persists for life. Information on age- and gender-specific seroprevalence of HSV-1 and HSV-2 is valuable for understanding HSV transmission dynamics and designing population-based prevention and intervention programs for HSV.

[Expression and clinical significance of IL-17 and IL-21 in patients with acute leukemia].

This study was aimed to investigate the effects of peripheral blood Th17 cells, IL-17 and IL-21 in the occurrence and development of acute leukemia. 60 patients with acute leukemia (19 patients with ALL, 41 patients with AML) were divided into non-remission group (group A, n=24), remission group (group B, n=36); 25 healthy volunteers were used as control group (group C). In addition to this, these 60 patients were divided into infection group (n=32) and non-infection group (n=28) on the basis of infection status.

In vitro observations on the influence of copper peptide aids for the LED photoirradiation of fibroblast collagen synthesis.

Objective: The purpose of this study was to evaluate the influence of Cu-GHK aids for the LED-PI on fibroblast proliferation and collagen production in vitro.

Background Data: Light-emitting diode photoirradiation (LED-PI) and copper-glycyl-L-histidyl-L-lysine complex (Cu-GHK) treatment may be useful in accelerating the rate of wound healing. Red LED (625-635 nm) was used as a light source for LED-PI.