Development of solid lipid nanoparticles containing total flavonoid extract from L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats.

Total flavonoid extract from L. (TFDM) contains effective components of L. that have myocardial protective function.

Improved Oral Bioavailability of Total Flavonoids of via Composite Phospholipid Liposomes: Preparation, Drug Release and Pharmacokinetics in Rats.

Background: L is a traditional Uygur medicine for centuries, total flavonoids extracted from are the major active ingredients of herbs, which possesses significant medicinal values to treat coronart disease and hypertension, due to the glycosyl group on the ring, total flavonoids of has low hydrophilic and poorly absorbed after oral administration, so one way is the formulation of poorly water soluble and permeabledrugs with lipids containing formulations such as Composite phospholipid liposomes to improve the absorption profile of drug.

Objectives: To prepare composite phospholipid liposome (CPL) encapsulatetotal flavonoids extract from (TFDM), determine its physicochemical properties, investigate its release and evaluate the pharmacokinetics in Sprague-Dawley (SD) rats to increase the bioavailability of TFDM-CPL.

Material And Methods: The TFDMCPL was prepared by the method of ammonium sulfate transmembrane gradients.

Optimization of the process variables of tilianin-loaded composite phospholipid liposomes based on response surface-central composite design and pharmacokinetic study.

Tilianin is attracting considerable attention because of its antihypertensive, anti-atherogenic and anticonvulsive efficacy. However, tilianin has poor oral bioavailability. Thus, to improve the oral bioavailability of tilianin, composite phospholipid liposomes were adopted in this work as a novel nanoformulation.