Impacts of the development of acute-on-chronic liver failure and bacterial infections on β-cell function and glucose homeostasis in patients with liver cirrhosis.

Background: The pathogenesis involved in glucose metabolism disorders (GMDs) in patients with liver cirrhosis remains unclear.

Aims: We investigated the effects of acute-on-chronic liver failure (ACLF) development and bacterial infections (BIs) on pancreatic β-cell function and glucose homeostasis in individuals with liver cirrhosis.

Methods: A retrospective analysis was conducted on 327 patients experiencing acute deterioration of liver cirrhosis.

AnnexinA5 Might Suppress the Phenotype of Human Gastric Cancer Cells ERK Pathway.

Gastric cancer is one of the most fatal diseases around the world. However, the mechanism of the development of gastric cancer is still not clarified. In addition, the anticancer drugs have cytotoxicity with different degrees.

Cinchona alkaloid derivative-catalyzed enantioselective synthesis via a Mannich-type reaction and antifungal activity of β-amino esters bearing benzoheterocycle moieties.

An efficient synthesis of highly functionalized chiral β-amino ester derivatives containing benzothiophene and benzothiazole moieties is developed by a Mannich-type reaction using a cinchona alkaloid-derived thiourea catalyst. The desired products were obtained in good yields and high enantioselectivities (~86% yield, >99% ee) using to the optimized reaction conditions. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR, and HREI-MS analyses.

Enantiomeric separation of indoxacarb on an amylose-based chiral stationary phase and its application in study of indoxacarb degradation in water.

Direct semipreparative enantioseparation of indoxacarb was performed on a semipreparative Chiralpak IA column using normal-phase high-performance liquid chromatography (HPLC) with n-hexane-isopropanol-ethyl acetate (70:20:10) mixture as mobile phase. Degradation of indoxacarb (2.33S + 1R) and its two enantiopure isoforms in three aqueous buffer solutions and four water samples collected from natural water sources was then elucidated by HPLC analysis on Chiralpak IA column.

Synthesis and anti-TMV activity of dialkyl/dibenzyl 2-((6-substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) malonates.

Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by 1H-NMR, 13C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity.