Publications by authors named "MeiFen Zhang"
Article Synopsis
- This study investigates the prevalence and risk factors of chemotherapy-induced taste alterations (CiTA) among cancer patients, which can lead to gastrointestinal issues and malnutrition.
- The analysis included 30 studies with over 15,000 participants, finding that 70% of patients experience CiTA, with prevalence varying widely between 21% and 100%.
- Key risk factors identified for developing CiTA include being female, having xerostomia or oral mucositis/ulcers, and undergoing at least two chemotherapy cycles; these findings suggest a need for targeted interventions in healthcare.
The efficacy of flipped classroom in ophthalmology education has not been well proved. This study aimed to investigate the efficacy of flipped classroom on diabetic retinopathy (DR) and glaucoma in ophthalmology education. Ninety-three medical students in Peking Union Medical College participated and were randomly assigned into two groups.
View Article and Find Full Text PDFAims: To identify the longitudinal trajectories of psychological distress and to explore the predictive factors of different trajectories among young and middle-aged colorectal cancer patients from diagnosis to 6 months postoperation.
Design: A longitudinal study was conducted, guided by the STROBE checklist.
Methods: A total of 214 patients were recruited from July 2021 to May 2022 at a cancer hospital in Guangzhou, China.
Purpose: Frailty is a syndrome caused by multiple factors and can lead to serious consequences for middle-aged and elderly patients with colorectal cancer. However, few studies have comprehensively explored predictors of frailty and built predictive models. Therefore, our aim is to develop and evaluate a predictive model for frailty in middle-aged and elderly patients with colorectal cancer.
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- The study evaluated levels of pro-inflammatory and anti-inflammatory cytokines in the aqueous humor of uveitis patients, both with and without glaucoma, and compared them to patients with primary open-angle glaucoma and age-related cataract.
- Using Luminex xMAP® multiplex assays, researchers analyzed 11 cytokines and found significant elevations in pro-inflammatory factors in the aqueous humor of those with uveitis-secondary glaucoma, suggesting a correlation with disease progression.
- The findings indicate that the presence of certain cytokines (like MCP-1, IL-6, and IL-8) might play a role in the glaucomatous changes seen in uveitis patients, and high intraocular pressure did not significantly affect cytokine levels before
Purpose: To explore the trajectories of acceptance of disability in young and middle-aged breast cancer patients based on a latent class growth analysis, investigate factors associated with each trajectory, and identify whether return to normal living differs in different trajectories.
Methods: Young and middle-aged patients newly diagnosed with breast cancer who underwent surgery were followed up at baseline, and 1, 3, and 6 months in China. Participants completed sociodemographic information questionnaires, the Adaptation of Disability Scale Revised, and the Reintegration to Normal Living Index.
Association between COVID-19 infection and uveitis flare in patients with Behcet's disease, a retrospective multicenter cohort study.
Graefes Arch Clin Exp Ophthalmol
August 2024
Purpose: To explore if COVID-19 infection and its subsequent immunosuppressant adjustment as well as previous vaccination status are associated with higher risks of uveitis flare in patients with Behcet's disease.
Methods: This retrospective multicenter cohort study was conducted in January 2023 among patients with Behcet's uveitis, during the second wave of the COVID-19 pandemic in China, with an anticipated sample size of 250. The primary objective was to examine the association between COVID-19 infection and the occurrence of uveitis flare.
Background: Significant concomitants of the sick role maladaptation in colorectal cancer (CRC) patients include inappropriate cognitions, emotional states, and overt conducts associated to disease. This protocol was developed to implement and evaluate the effects of a self-led, virtual reality-based cognitive behavioral therapy (VR-CBT) on the sick role adaptation among working-age CRC patients.
Methods: This is an assessor-blinded, randomized controlled trail that adheres to the SPIRIT 2013 Statement guidelines.
Purpose: Behçet's disease-associated uveitis (BDU) is a severe, recurrent inflammatory condition affecting the eye and is part of a systemic vasculitis with unknown etiology, making biomarker discovery essential for disease management. In this study, we intend to investigate potential urinary biomarkers to monitor the disease activity of BDU.
Methods: Firstly, label-free data-dependent acquisition (DDA) and tandem mass tag (TMT)-labeled quantitative proteomics methods were used to profile the proteomes of urine from active and quiescent BDU patients, respectively.
Article Synopsis
- The study investigates different patterns of psychosocial adjustment in young to middle-aged women with breast cancer and identifies factors affecting these patterns.
- Conducted over three years, it involved 377 participants, with evaluations at several points after surgery, revealing three main adjustment trajectories: severe maladjustment, moderate maladjustment, and well-adjusted.
- Key factors influencing these trajectories include the side of breast affected, type of surgery, chemotherapy treatment, levels of self-efficacy, social support, and coping strategies.
Purpose: To develop a more tailored immunomodulatory treatment (IMT) strategy based on a novel 2-arm risk stratification system in Vogt-Koyanagi-Harada (VKH) patients.
Design: A retrospective clinical cohort study.
Methods: Seventy-nine VKH patients in the acute stage were stratified into low- (n = 58) and high-risk (n = 21) groups based on their exposure to risk factors.
Background: Although neuromyelitis optica spectrum disorder (NMOSD) has high recurrence and disability rates, cases of relapses can be recognized, and timely intervention can be provided if the risk of relapse is properly perceived. However, there have been no studies to explore patients' perceptions of recurrence risk and coping strategies. This study aimed to explore the characteristics of relapse risk perception and coping strategies of patients with NMOSD.
View Article and Find Full Text PDFPurpose: To evaluate the effect of telehealth interventions on adherence to endocrine therapy among patients with breast cancer.
Methods: A systematic search of five English databases (PubMed, Web of Science, Embase, the American Psychological Association PsycNet, and the Cochrane Library) and four Chinese databases (Chinese National Knowledge Infrastructure, SinoMed, WanFang Data, and WeiPu Data) was performed from inception to March 31, 2023. Two investigators independently screened the available studies for eligibility and extracted relevant data.
Context: While guidelines have been formulated for the management of primary aldosteronism (PA), following these recommendations may be challenging in developing countries with limited health care access.
Objective: We aimed to assess the availability and affordability of health care resources for managing PA in the Association of Southeast Asian Nations (ASEAN) region, which includes low-middle-income countries.
Methods: We instituted a questionnaire-based survey to specialists managing PA, assessing the availability and affordability of investigations and treatment.
Background: There are many risk factors for severe acute pancreatitis (SAP) complicated with acute gastrointestinal injury (AGI), but few reports on the interaction between these risk factors.
Aim: To analyze the risk factors for SAP complicated with AGI and their interactive effects.
Methods: We selected 168 SAP patients admitted to our hospital between December 2019 and June 2022.
Objective: To describe the social participation and acceptance of disability (AOD) in young and middle-aged patients with breast cancer after surgery and their dynamic trajectories and to explore the critical factors associated with social participation.
Methods: 212 young and middle-aged patients with breast cancer after surgery were recruited for a 6-month follow-up study, and 158 of whom completed four surveys. Participants were asked to complete questionnaires including a general information questionnaire, Social Dysfunction Screening Scale, and Adaptation of Disability Scale Revised at baseline, and at 1, 3, and 6 months.
Purpose: To examine the psychosocial adjustment of young to middle-aged women who were newly diagnosed with breast cancer and to determine the comprehensive risk factors contributing to psychosocial adjustment.
Methods: This study was carried out on 358 young to middle-aged women who recently received a breast cancer diagnosis in two hospitals in Guangzhou, China. Participants reported data about sociodemographic characteristics, disease and treatment information, coping modes, social support, self-efficacy, and psychosocial adjustment.
Aim: To determine the associated factors of professional identity among intensive care unit (ICU) nurses during the COVID-19 pandemic in China.
Design: Multicentre cross-sectional study.
Methods: This study invited 348 ICU nurses in five hospitals in China from May to July 2020.
Aims And Objectives: The aim of this study was to describe the prevalence of reproductive concerns among young female patients with colorectal cancer and explore the associated factors.
Background: With the trend of longer survival and younger age at diagnosis of colorectal cancer patients, reproductive concerns have become increasingly prevalent among young female colorectal cancer patients.
Design: Cross-sectional design.
Long-term proton pump inhibitor (PPI) use has been associated with hypomagnesemia. It is unknown how frequently PPI use is implicated in patients with severe hypomagnesemia, and its clinical course or risk factors. All patients with severe hypomagnesemia from 2013 to 2016 in a tertiary center were assessed for likelihood of PPI-related hypomagnesemia using Naranjo algorithm, and we described the clinical course.
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