[Association between genetic polymorphism of erythrocyte CR1 and the susceptibility of idiopathic pulmonary fibrosis].

Objective: To explore the association between the erythrocyte CR1 genomic density polymorphism, A3650G site polymorphism and the susceptibility of idiopathic pulmonary fibrosis (IPF); and to investigate the correlation between the HindIII density polymorphism of CR1 gene and the quantitative levels of E-CR1 in IPF patients.

Methods: Blood samples from IPF patients (n = 64) and ethnically matched healthy controls (n = 54) were taken from a population-based case-control association study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to identify the genotype of the HindIII restriction fragment length polymorphism of CR1 gene and SNP A3650G in two groups.