Bibliometric analysis of tuberculosis molecular epidemiology based on CiteSpace.

Background: Tuberculosis is a communicable disease that is a major cause of ill health. Bibliometrics is an important statistical methodology used to analyze articles and other publications in the literature study. In this study, publications on molecular epidemiology were analyzed using bibliometric analysis.

Molecular Signatures Related to the Virulence of Bacillus cereus Sensu Lato, a Leading Cause of Devastating Endophthalmitis.

endophthalmitis is a devastating eye infection that causes rapid blindness through extracellular tissue-destructive exotoxins. Despite its importance, knowledge of the phylogenetic relationships and population structure of intraocular spp. is lacking.

Activities of Biapenem against Mycobacterium tuberculosis in Macrophages and Mice.

Objective: To assess the activities of biapenem against multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis.

Methods: Biapenem/clavulanate (BP/CL) was evaluated for in vitro activity against Mycobacterium tuberculosis (Mtb) multidrug-resistant (MDR) isolates, extensively drug-resistant (XDR) isolates, and the H37RV strain. BP/CL activity against the H37Rv strain was assessed in liquid cultures, in macrophages, and in mice.

Genetic signatures of high-altitude adaptation in Tibetans.

Indigenous Tibetan people have lived on the Tibetan Plateau for millennia. There is a long-standing question about the genetic basis of high-altitude adaptation in Tibetans. We conduct a genome-wide study of 7.

Identification of novel mutations by targeted exome sequencing and the genotype-phenotype assessment of patients with achromatopsia.

Background: Achromatopsia (ACHM) is a severe congenital autosomal recessive retinal disorder caused by loss of cone photoreceptors. Here, we aimed to determine the underlying genetic lesions and phenotypic correlations in two Chinese families with ACHM.

Methods: Medical history and clinical evaluation were obtained from both families.

CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients.

Background: Complement Factor I (CFI) and the CD46 complement regulator (CD46) play an important role in the complement activation pathways, which is known to affect the development of uveitis. The present study was performed to investigate the association of the CFI and CD46 genes with acute anterior uveitis (AAU).

Methods: A total of 600 subjects (300 patients with AAU and 300 healthy controls) were recruited for this case-control study.

[A preliminary study on immune adjunctive therapy for multidrug-resistant Mycobacterium tuberculosis infection in animal models].

Objective: To investigate the effect of adjunctive therapy by immune agents in mice infected with multidrug-resistant tuberculosis (MDR-TB).

Methods: Sixty-eight adult male BALB/c mice were infected with multidrug-resistant Mycobacterium tuberculosis (MTB) by aerosol route. The mice were randomly divided into a control group, an immuno-treatment group, a drug treatment group and a combination treatment group (drug plus immuno-treatment).

Clinical analysis of 240 patients with HLA-B27 associated acute anterior uveitis.

Purpose: To analyze the prevalence of HLA-B27 associated acute anterior uveitis and to identify its clinical features.

Methods: A total of 240 patients with HLA-B27 associated acute anterior uveitis, who were admitted to Zhejiang Ophthalmologic Hospital between December 2006 and October 2012, were retrospectively analyzed. The age of onset, sex, affected eyes, HLA-B27 antigen detection, recurrence, joint involvement, and surgical complications were investigated.

Synthesis and anti-tubercular activity of novel alkyl substituted riminophenazine derivatives.

A series of novel riminophenazine derivatives bearing an alkyl substituent attached to N-5 and imino nitrogen at C-3 position of the phenazine ring were obtained through rational drug design, aiming to maintain high anti-tubercular activity, lower toxicity and reduce lipophilicity. All target compounds were prepared by utilizing simple and flexible synthetic route and evaluated against Mycobacterium tuberculosis H37Rv and screened for mammalian cytotoxicity. The results demonstrated that compounds with a cyclopropyl substituent at N-5 position were more active than the reference compound clofazimine.

[A study on the activity of clofazimine with antituberculous drugs against Mycobacterium tuberculosis].

Objective: To explore the role of clofazimine in combination with other antituberculous drugs against Mycobacterium tuberculosis.

Methods: The minimal inhibitory concentration (MIC) of each drug and the drugs in combination against M. tuberculosis H₃₇Rv were determined, and the synergetic activities according to the fractional inhibitory concentration (FIC) formula was calculated.

[Tissue distribution and deposition of clofazimine in mice following oral administration of isoniazid].

Objective: Tissue distribution and deposition of clofazimine in mice were investigated following administration of clofazimine with or without isoniazid.

Methods: Kunming mice were given clofazimine suspension orally at a daily dose of 13 mg/kg body weight either alone or with isoniazid (25 mg/kg body weight) for a single dose or for 1 or 2 months. Tissues (liver, lung, spleen, small intestine, kidneys, fat) and pooled plasma were analyzed for clofazimine in all the treated groups by high-performance liquid chromatography.

[Activities of clofazimine against Mycobacterium tuberculosis in vitro and in vivo].

Objective: To evaluate the in vitro and in vivo antituberculous activities of clofazimine.

Methods: The MIC of clofazimine against H(37)Rv and 30 MDR-TB clinical strains were determined by microplate Alamar blue assays. Female BALB/c mice were infected with M.

[Analysis of single nucleotide polymorphism in the human beta-globin gene of patients with minor beta-thalassemia from Wenzhou].

This study was aimed to analyze the hematologic and molecular biologic characteristics of 14 Wenzhou patients with minor beta-thalassemia, to find out the mutation sites responsible for the disease by detecting sequences of PCR products and to analyze the single nucleotide polymorphism. The peripheral blood of patients was collected intravenously and was anticoagulated with EDTA-K(2); then the templates from blood samples were extracted, the related primers were designed for sequencing the products amplified by PCR; finally mutation sites resulting in beta-thalassemia were found through comparison and analysis of sequences. The results indicated that the C-->T heterozygous mutation occurred at the IVS-2 -654 site in 4 cases; the TTCT deficiency appeared at CD41/42 site in 1 case; in 2 sites existed single nucleotide polymorphisms occurring at the 59th site of exon 1 (T/C, CAT/CAC, His) and IVS-2 nt 665 (T/C).