Type 2 diabetes(T2DM) is a metabolic disorder marked by glucose toxicity, lipotoxicity, insulin resistance, and other pathological manifestations, representing a pressing global health concern. Obesity stands out as a pivotal risk factor for T2DM development. When combined with T2DM, obesity exacerbates insulin resistance and metabolic abnormalities.
View Article and Find Full Text PDFObesity has been identified as a chronic low-grade systemic inflammation and a key risk factor for diseases such as diabetes, hypertension, and malignancies, and has become an urgent global health burden. Adipose tissue macrophages play a significant role in adipose immune homeostasis and inflammatory responses. Under different conditions, they can be polarized into pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype.
View Article and Find Full Text PDFAerobics is the fusion of gymnastics, dance, and music; it is a body of a sports project, along with the development of the society. The growing demand for aerobics inevitably increases the demand for aerobics coach and teacher and has opened elective aerobics class which is an effective way of cultivating professional talents relevant to aerobics. Aerobics has extended fixed teaching mode and cannot conform to the development of the times.
View Article and Find Full Text PDFWild grapevines can show strong resistance to the downy mildew pathogen P. viticola, but the associated mechanisms are poorly described, especially at early stages of infection. Here, we performed comparative proteomic analyses of grapevine leaves from the resistant genotype V.
View Article and Find Full Text PDFThe downy mildew disease in grapevines is caused by . This disease poses a serious threat wherever viticulture is practiced. Wild species showing resistance to offer a promising pathway to develop new grapevine cultivars resistant to which will allow reduced use of environmentally unfriendly fungicides.
View Article and Find Full Text PDF