Publications by authors named "Mei-feng Wang"
Objectives: The impact of ineffective esophageal motility (IEM) on gastroesophageal reflux disease (GERD) remains unknown, and abnormal esophageal motility often coexists with abnormal gastric motility. We aimed to investigate the role of IEM in GERD and its relationship with gastric electrical activity.
Methods: Patients diagnosed as GERD based on GERD-questionnaire score ≥8 in our hospital from January 2020 to June 2022 were included.
Article Synopsis
- - The study aimed to compare how effectively lansoprazole (LPZ), pantoprazole (PPZ), and their stereoisomers reduce stomach acid in healthy Chinese participants after administering intravenous doses.
- - Participants received either LPZ, R-LPZ, PPZ, or S-PPZ via intravenous infusion, and their stomach pH levels were monitored for 24 hours before and after treatment to assess the drugs' acid inhibition effects.
- - Results showed that R-LPZ and LPZ were generally more effective than S-PPZ and PPZ in inhibiting stomach acid, with statistically significant differences noted in their performance after both a single and multiple doses.
Objective: To explore the correlation between reflux disease and abnormal esophageal motility in patients with gastroesophageal reflux disease (GERD).
Methods: Participants (patients with GERD and controls) who underwent 24-h impedance-pH monitoring (MII-pH monitoring) and high-resolution manometry between January 2012 and February 2017 were retrospectively studied. The patients were divided into two groups (acid reflux and nonacid reflux) based on their MII-pH monitoring data.
Article Synopsis
- The study aimed to assess the safety, pharmacokinetics (how the drug moves in the body), and pharmacodynamics (how it affects the body) of S-(-)-pantoprazole sodium injections in healthy Chinese participants after various dosage administrations.
- Subjects received different single and multiple intravenous doses (20 mg, 40 mg, and 80 mg) of S-(-)-PPZ and were monitored for safety and effects on intragastric pH.
- Results showed that S-(-)-PPZ was safe with mild side effects, and the higher doses resulted in increased acid suppression compared to lower doses or the traditional pantoprazole, suggesting it may provide more effective acid inhibition.
Not all patients with acid-related disorders receiving proton pump inhibitor (PP) treatment get adequate gastric pH control. The genetic variation of receptors, metabolic enzymes, and transporters are known to cause failures of therapies. We have conducted a study to evaluate the influence of gastric , and polymorphisms on the pharmacokinetic and pharmacodynamic profiles of dexlansoprazole injection in healthy Chinese subjects.
View Article and Find Full Text PDFPurpose: This study was conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of dexlansoprazole injection in healthy subjects.
Methods: Dexlansoprazole (20-90 mg) or lansoprazole (30 mg) was administrated intravenously to healthy male and female volunteers. All the subjects were sampled for pharmacokinetic (PK) analysis and 64 of them were monitored for 24-h intragastric pH prior to and after administration in the pharmacodynamic (PD) study.
Objective: To study the effect of total flavonoids of Astmgali Radix (TFA) on liver cirrhosis induced with dimethylnitrosamine (DMN) in rats, and the effect on peroxisome proliferator-activated receptor γ (PPARγ), uncoupling protein 2 (UCP2) and farnesoid X receptor (FXR).
Methods: Fifty-three Sprague-Dawley rats were randomly divided into a control group (10 rats) and a DMN group (43 rats). Rats in the DMN group were given DMN for 4 weeks and divided randomly into a model group (14 rats), a low-dosage TFA group (14 rats) and a high-dosage TFA group (15 rats) in the 3rd week.
Age-related symptom and life quality changes in women with irritable bowel syndrome.
World J Gastroenterol
December 2012
Aim: To explore age-related changes in symptoms and quality of life (QoL) of women with irritable bowel syndrome (IBS).
Methods: Two-hundred and fifty-four female adult outpatients with IBS attending the Department of Gastroenterology at the First Affiliated Hospital of Nanjing Medical University between January, 2008 and October, 2008 were approached. Patients with a history of abdominal surgery, mental illness or those who had recently taken psychotropic drugs were excluded.
Aim: The aim of the study was to evaluate the changes in symptoms and quality of life in people with puborectalis dyssynergia after biofeedback by using Short Form-36 and Patient Assessment of Constipation Quality of Life Questionnaire.
Background: Biofeedback is an effective treatment in clinical symptoms for puborectalis dyssynergia. However, little is known about the degree of the variation in the quality of life for these people after biofeedback.
Objective: To explore the effect and the intracellular signal transduction pathway of insulin-like growth factor 1 (IGF-1) on the expression of stem cell factor (SCF) in gastric smooth muscle cells (SMC).
Methods: Gastric SMC from SD rats were cultured by enzymolysis and identified by α-actin immunofluorescence methods. Western blot and quantitative reverse transcription-polymerase chain reaction were used to examine the expression of SCF in gastric SMC:(1) The level of SCF after gastric SMC were cultured with IGF-1.
Objective: To explore the effects of biofeedback training on clinical symptom, psychological state and quality of life in patients with functional constipation (FC).
Methods: Forty-nine patients with FC diagnosed by Rome III were enrolled and received biofeedback training. Bowel symptom measure, Zung's self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Chinese version of the MOS 36-item short form healthy survey (SF-36) were recorded to assess the effects before and after treatment.